Allgemeine Toxikologie II - Institut für Analytische Chemie

Bewertung der Umweltgefährlichkeit von Chemikalien
1. Expositionsanalyse
Predicted Environmental Concentration (PEC)
Monitoring Daten (soweit vorhanden), Modellrechnungen
2. Wirkungsanalyse
No Effect Concentration (NOEC)
Ersatzweise: EC 50 , LC 50
Predicted No-Effect Concentration (PNEC)
Einzelspezies, Mesokosmosstudien
(EC50 , Konz., die eine bestimmte Wirkung in 50% der Spezies erzeugt)
LC50 , niedrigste Konzentration, die zum Tod von 50% der Spezies führt)
Assessment factors to derive a PNEC aquatic
Available data
At least one short-term L(E)C50 from each of
three trophic levels of the base-set (fish,
Daphnia, algae)
One long-term EC10 or NOEC (either fisch or
Daphnia)
Two long-term results (e.g. EC10 or NOECs)
from species representing two trophic levels
(fish and/or Daphnia and/or algae)
Long-term results (e.g. EC10 or NOECs) from at
least three species (normally fish, Daphnia and
algae) representing three trophic levels
Species-Sensitivity-Distribution (SSD)-method
(statistical method)
Field data or model ecosystems
Assessment factor
1000
100
50
10
5-1
(to be fully justified case by case)
Reviewed on a case by case basis
GUIDANCE ON INFORMATION REQUIREMENTS AND CHEMICAL SAFETY ASSESSMENT
Chapter R.10: Characterisation of dose/concentration-response for environment
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