2006 ที่น้องแอนทำ.pmd - Mahidol University

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Mahidol University Abstract of International Publications 2006 No.842 Author(s) : Sawasdee N, Udomchaiprasertkul W, Noisakran S, Rungroj N, Akkarapatumwong V, Yenchitsomanus PT. Title : Trafficking defect of mutant kidney anion exchanger 1 (kAE1) proteins associated with distal renal tubular acidosis and Southeast Asian ovalocytosis. Source : Biochemical and Biophysical Research Communications. 350(3):723–730, 2006 (Nov). Document Type : Article. Keywords : Distal renal tubular acidosis (dRTA), Kidney anion exchanger 1 (kAE1), Southeast Asian ovalocytosis (SAO), Compound heterozygous mutation, Trafficking defect, Epitope tag, Green fluorescent protein (GFP), Thai. Abstract : Compound heterozygous anion exchanger I (AE1) SAO/G701D mutations result in distal renal tubular acidosis with Southeast Asian ovalocytosis. Interaction, trafficking and localization of wild – type and mutant (SAO and G701D) kAE1 proteins fused with hemagglutinin, six – histidine, Myc, or green fluorescence protein (GFP) were examined in human embryonic kidney (HEK) 293 cells. When individually expressed, wild – type kAE1 was localized at cell surface while mutant kAE1 SAO and G701D were intracellularly retained. When co – expressed, wild – type kAE1 could form heterodimer with kAE1 SAO or kAE1 G701D and could rescue mutant kAE1 proteins to express on the cell surface. Co – expression of kAE1 SAO and kAE1 G701D also resulted in heterodimer formation but intracellular retention without cell surface expression, suggesting their trafficking defect and failure to rescue each other to the plasma membrane, most likely the molecular mechanism of the disease in the compound heterozygous condition. No.843 Author(s) : Sawathiparnich P, Osuwanaratana P, Santiprabhob J, Likitmaskul S. Title : Tamoxifen improved final height prediction in a girl with McCune – Albright syndrome: Patient report and literature review. Source : Journal of Pediatric Endocrinology & Metabolism. 19 (1): 81 – 86, 2006 (Jan). Document Type : Review. Keywords : McCune – Albright syndrome, Tamoxifen, Precocious puberty, Raloxifene, Predicted adult height. Abstract : McCune – Albright syndrome (MAS) is characterized by gonadotropin – independent precocious puberty, cafe – au – lait spots on the skin and polyostotic fibrous dysplasia of bones. Treatment of precocious puberty (PP) in MAS should be considered in patients with poor predicted adult height (PAH). Treatment of gonadotropin – independent PP in MAS with ketoconazole, cyproterone acetate or testolactone, an aromatase inhibitor, does not appear to be always effective in slowing bone maturation. We report here a Thai girl with MAS who received tamoxifen, one of the selective estrogen receptor modulators, for the management of advanced puberty and rapid bone maturation. Her pubertal progression, vaginal bleeding, growth rate and PAH improved during treatment with tamoxifen despite persistently elevated serum estradiol levels and an enlarged ovarian cyst. No.844 Author(s) : Sawatsuk T, Shiowatana J, Siripinyanond A. Title : Matrix removal and analyte preconcentration before inductively coupled plasma spectrometric detection: use of a laboratory – made hollow fibre flow filtration unit. Source : Journal of Analytical Atomic Spectrometry. 21 (11): 1331 – 1335, 2006. Document Type : Article. Keywords : Atomic emission – spectrometry, Mass – spectrometry, Soluble polymers, Ultrafiltration. Abstract : A hollow fibre flow filtration (HF – FF) was applied to perform matrix removal and analyte preconcentration before inductively coupled plasma optical emission spectrometric (ICP – OES) detection. Poly(ethylene imine), PEI, with a molecular weight of 750 000 Da, was added to test solutions to form complexes with analyte elements (Ag, Cd, Co, Cu, Hg, Ni, Pb and Zn) but not the matrix elements (Ca, K, Mg and Na). Two flow streams were applied in opposing directions to introduce a large sample volume into the fibre membrane. With the use of a HF membrane made of poly(sulfone), having a pore size of 30 000 Da, matrix elements were removed by filtering off through the membrane, whereas the PEI – analyte complexes remained in the channel and were subsequently eluted and detected. Various parameters were optimized to obtain a satisfactory matrix removal and preconcentration factor. These include PEI concentration, focusing time, and focusing point. With a PEI concentration of 200 mg l(–1), focusing time of 15 min and the focusing point nearest to the detector, matrix removal efficiency was nearly 100%. 302
Mahidol University Abstract of International Publications 2006 No.845 Author(s) : Say EC, Nakajima M, Senawongse P, Soyman M, Ozer F, Ogata M, Tagami J. Title : Microtensile bond strength of a filled vs unfilled adhesive to dentin using self – etch and total – etch technique. Source : Journal of Dentistry. 34 (4): 283 – 291, 2006 (Apr). Document Type : Article. Keywords : Filled adhesive, Unfilled adhesive, Total – etch, Self – etch. Abstract : Objective: The purpose of this study was to evaluate the effect of a filled adhesive (One – Step Plus; Bisco) versus an unfilled adhesive (One – Step; Bisco) on the microtensite bond strength (mu TBS) to dentin using total – etch (Uni – etch; Bisco) and self – etch (Tyrian SPE; Bisco) techniques. Methods: Twenty extracted human third molars were ground flat to expose occlusal dentin. After the dentin surfaces were polished with 600 – grit SiC paper, the teeth were randomly assigned to four groups according to the bonding agent and technique being used. Dentin surfaces were bonded with One – Step Plus + total – etch; One – Step Plus+self – etch; One – Step+ total – etch and One – Step + self – etch. Composite buildups were performed with Clearfil AP – X (Kuraray Medical). Following storage in distilled water at 37 degrees C for 24 h, the bonded specimens were serially sectioned into 0.7 mm – thick stabs and then trimmed to hour – glass shapes with a 1 mm 2 cross – sectional area (n = 20). Microtensile bond strengths were determined using the EZ – test (Shimadzu) at a cross – head speed of 1 mm/min. Data were analyzed using two – way ANOVA and Tukey’s post hoc test. Results: There were no significant differences in the mu TBS between One – Step Plus and One – Step adhesives when they were used with the total – etch and self – etch techniques (p > 0.05). However with the total – etch technique both adhesives yielded significantly higher bond strength values than the self – etch technique (p < 0.001). Conclusion: The fitted adhesive One – Step Plus did not show any beneficial effect than the unfilled adhesive One – Step on the mu TBS to dentin with total – etch and self – etch techniques. Irrespective from the adhesive type, self – etch technique revealed lower bond strengths than the total – etch technique. No.846 Author(s) : Scott TW, Gerade B, Harrington LC, Jones JW, Edman JD, Kitthawee S, Minnick SL, Clark JM. Title : Age – structure of Aedes aegypti populations and intra – annual variation in dengue transmission. Source : American Journal of Tropical Medicine and Hygiene. 75 (5): 210 – 210 726 Suppl. S, 2006 (Nov). Document Type : Meeting Abstract. Keywords : – Abstract : – No.847 Author(s) : Seeherunvong W, Nwobi O, Abitbol CL, Chandar J, Strauss J, Zilleruelo G. Title : Paricalcitol versus calcitriol treatment for hyperparathyroidism in pediatric hemodialysis patients. Source : Pediatric Nephrology. 21 (10): 1434 – 1439, 2006 (Oct). Document Type : Article. Keywords : Paricalcitol, Calcitriol, Hyperparathyroidism, Children, Young adults, Hemodialysis. Abstract : Secondary hyperparathyroidism (SHPT) remains a treatment dilemma in pediatric dialysis patients. Recent experience with paricalcitol (P), a vitamin D analogue, in adults with SHPT has shown equal efficacy and improved survival compared to traditional treatment with calcitriol (C). We present our experience with (C) compared to (P) treatment in our pediatric dialysis patients with SHPT. Twenty – one patients (mean age 11.5 +/– 5 years) with SHPT (intact parathyroid hormone (iPTH) averaging 1,228 +/– 496 pg/ml) were studied. Seventeen received (C) followed by (P); while an additional four were treated with either (C=1) or (P=3) alone. After 26 +/ – 8 weeks, average percent (%) decrease in iPTH was similar with (C) and (P) (– 60.4 +/– 34% versus – 65.4 +/– 28%, respectively; p=0.6). In the (P) group, the effective dose in children was greater than in adult trials based on kilogram weight. Episodes of hypercalcemia between the treatment groups were not different. However, episodes of elevated calcium x phosphorus product (CaxP)>= N70 mg(2)dl(2) occurred more frequently in the (C) group (odds ratio=1.5; p=0.01). Paricalcitol appears to be safe and effective in pediatric patients. Data suggest that dosing should be gauged according to degree of SHPT. This should serve as impetus for future pharmacokinetic studies in pediatric dialysis patients. 303
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2006 ที่น้องแอนทำ.pmd - Mahidol University

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