2006 ที่น้องแอนทำ.pmd - Mahidol University

Mahidol University Abstract of International Publications 2006
No.120
Author(s) : Busaranon K, Suntornsuk W, Suntornsuk L.
Title : Comparison of UV spectrophotometric method and high performance liquid
chromatography for the analysis of flunarizine and its application for the dissolution
test.
Source : Journal of Pharmaceutical and Biomedical Analysis. 41 (1): 158 – 164, 2006 (Apr).
Document Type : Article.
Keywords : Flunarizine, UV spectrophotometric method, High performance liquid
chromatography, Dissolution test.
Abstract : This study aimed to develop a simple UV spectrophotometric method for the analysis
and the dissolution test of flunarizine in capsules. The UV absorbance was both
measured directly and by the first derivative measurements at 254 and 268 nm,
respectively. The developed methods were validated for their linearity, accuracy,
precision, limit of detection (LOD) and limit of quantitation (LOQ) in comparison with
the reported HPLC method. The UV spectrophotometric method illustrated excellent
linearity (r(2) > 0.9999) in the concentration range of 6 – 24 mu g/mL. Precision
(%R.S.D. < 1.50) and recoveries were good (%R > 99.62). The LOD of direct UV and
first derivative measurements were 0.09 and 0.84 mu g/mL, respectively, and the
LOQ were 0.26 and 2.55 mu g/mL, respectively. Results from the assay of flunarizine
in capsules by the UV spectrophotometric methods, both direct and first derivative
measurements were not significantly different from those of the HPLC method (P >
0.05). Additionally, the method was successfully used for the dissolution test of
flunarizine capsule and was found to be reliable, simple, fast, and inexpensive.
No.121
Author(s) : Bussaratid V, Desakorn V, Krudsood S, Silachamroon U, Looareesuwan S.
Title : Efficacy of ivermectin treatment of cutaneous gnathostomiasis evaluated by placebo
– controlled trial.
Source : Southeast Asian Journal of Tropical Medicine and Public Health. 37(3):433–440, 2006.
Document Type : Article.
Keywords : –
Abstract : Previous studies have revealed that ivermectin treatment for gnathostomiasis can
reduce parasitic loads in animals and make recurrent subcutaneous swelling subside
in 76% of patients. Our study aimed to evaluate the efficacy of ivermectin for
cutaneous gnathostomiasis treatment in a placebo – controlled trial. This study was a
prospective randomized placebo – controlled study performed at The Bangkok Hospital
for Tropical Diseases, Mahidol University, Thailand. Thirty patients with a serologically
confirmed diagnosis of cutaneous gnathostomiasis were enrolled. Seventeen patients
in the ivermectin treated group received a single dose of 12 mg ivermectin (200 g/kg
bodyweight), while 13 patients in the control group received a single dose of 40 mg of
vitamin B1. The follow – up period was 1 year. Of the 17 patients, 7 (41.2%) responded
to ivermectin, while no patient responded to placebo. The mean (95% CI) time to the
first recurrence of subcutaneous swelling with ivermectin and in the placebo groups
were 257 (184 – 331) and 146 (42 – 250) days, respectively, (p=0.102). Although this
study revealed no significant difference in the mean time to first recurrence of
swelling between the ivermectin and placebo groups, there was a trend towards
ivermectin efficacy against gnathostomiasis in previous animal and human studies.
Further studies with different doses of ivermectin and larger sample sizes, and close
monitoring for ivermectin tolerability and treatment response are necessary to confirm
an efficacy of ivermectin.
No.122
Author(s) : Butthep P, Chunhakan S, Tangnararatchakit K, Yoksan S, Pattanapanyasat K,
Chuansumrit A.
Title : Elevated soluble thrombomodulin in the febrile stage related to patients at risk for
dengue shock syndrome.
Source : Pediatric Infectious Disease Journal. 25 (10):894–897, 2006 (Oct).
Document Type : Article.
Keywords : Dengue hemorrhagic fever/dengue shock syndrome, Soluble thrombomodulin,
Circulating endothelial cells.
Abstract : Background: Children with dengue hemorrhagic fever (DHF) are at risk to develop
dengue shock syndrome (DSS) for which neither marker has been demonstrated.
Objective: The study was designed to investigate the markers of vascular endothelial
cell injuries and dysfunction that might be used as early predictors of the subsequent
manifestation of DSS. Methods: The blood samples from 111 patients with dengue
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