2006 ที่น้องแอนทำ.pmd - Mahidol University

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Mahidol University Abstract of International Publications 2006 No.1066 Author(s) : Tunapan M, Somsup C, Chairat S. Title : On a type of matrix ring. Source : Bulletin of the Australian Mathematical Society. 73 (1): 65 – 68, 2006 (Feb). Document Type : Article. Keywords : – Abstract : In this note we discuss a type of matrix ring that has nice properties concerning the injectivity and quasi – injectivity of one – sided ideals. No.1067 Author(s) : Tuncer V, Unsworth MJ, Siripunvaraporn W, Craven JA. Title : Audio – magnetotelluric exploration for unconformity uranium deposits in the Athabasca Basin, Saskatachewan, Canada. Document Type : Article. Source : SEG Technical Program Expanded Abstracts. 25 (1): 1328 – 1332, 2006 (Jan). Keywords : – Abstract : Audio – magnetotelluric (AMT) exploration is being evaluated as a tool for locating unconformity related uranium deposits in the Athabasca Basin in Canada. These uranium deposits are often located above graphitic basement conductors that can be located with electromagnetic (EM) methods. A test survey at the McArthur River Mine showed good agreement between the known location of the uranium deposit and that inferred from the AMT data. Electrical resistivity models derived by 2D inversion were validated by comparison with 3D inversion and correlation with well log data. This validation was also tested with 3D forward modeling and 2D synthetic inversions. No.1068 Author(s) : Tuncer V, Unsworth MJ, Siripunvaraporn W, Craven JA. Title : Exploration for unconformity – type uranium deposits with audiomagnetotelluric data: A case study from the McArthur River mine, Saskatchewan, Canada. Source : Geophysics. 71 (6): B201 – B209, 2006 (Nov – Dec). Document Type : Article. Keywords : Magnetotelluric inversion. Abstract : Unconformity – type deposits supply a significant amount of the world’s uranium and consist of uranium that is generally codeposited with graphite in a fault zone. The low resistivity of the graphite produces a significant contrast in electrical resistivity, which can be located with electromagnetic (EM) methods. The Athabasca Basin in Western Canada hosts significant uranium deposits, and exploration in deeper parts of the basin has required the application of new EM methods. This paper presents an evaluation of the audiomagnetotelluric (AMT) exploration method at the McArthur River mine in the Athabasca Basin. AMT data were collected at 132 stations on a grid, and two – dimensional (2D) and three – dimensional (3D) inversions were used to generate resistivity models. These models showed two major results: (1) a significant conductor coincident with a major basement fault (P2) and the uranium deposits (this conductor begins at the unconformity at a depth of 550 m and extends to a depth of at least three km) and (2) a resistive halo which might be caused by the silicification associated with mineralization. However, synthetic inversions showed that this halo could be an artifact of smoothing function in the inversion scheme. The 2D inversions were validated by synthetic inversions, comparison with the 3D inversion models, and correlation with well – log information. 3D AMT forward modeling showed that strong 3D effects are not present in the AMT impedance data. Induction vectors showed more evidence of complexity, but the inclusion of these data in the inversion improved subsurface resolution. No.1069 Author(s) : Tungkasereerak P, Ong – Ajyooth L, Chaiyasoot W, Ong – Ajyooth S, Leowattana W, Vasuvattakul S, Vareesangthip K, Shayakul C, Chanchairujira T, Sritippayawan S. Title : Effect of short – term folate and vitamin B supplementation on blood homocysteine level and carotid artery wall thickness in chronic hemodialysis patients. Source : Journal of the Medical Association of Thailand. 89 (8): 1187 – 1193, 2006. Document Type : Article. Keywords : Atherosclerosis, Carotid artery wall thickness, Folate, Hemodialysis, Homocysteinemia, Vitamin B12, Vitamin B6. Abstract : Objective: Hyperhomocysteinemia is an independent risk factor for atherosclerotic vascular disease in chronic hemodialysis patients. This stratified randomized controlled 384
Mahidol University Abstract of International Publications 2006 trial was designed to measure the effect of high dose oral vitamin B6, vitamin B12, and folic acid on homocysteine levels, and to evaluate the effect on atherosclerosis as measured by Intima – Media Thickness (IMT) of carotid arteries. Material and Method: Fifty – four chronic hemodialysis patients with hyperhomocysteinemia were randomized to receive oral 15 mg folic acid, 50 mg vitamin B6, and 1 mg vitamin B12 daily (treatment group) or oral 5 mg folic acid alone (control group) for 6 months. Homocysteine level and IMT were measured in both groups. Results: At 6 months, homocysteine levels in the treatment group were significantly reduced from 27.94 8.54 to 22.71 3.68 mmol/l (p = 0.009) and were not significantly increased from 26.81 7.10 to 30.82 8.76 mmol/l in control group (p = 0.08). Mean difference between both groups was statistically significant (p = 0.002). There was no significant difference of IMT of carotid arteries, however, a tendency that the treatment group would have less thickness was observed (0.69 0.29 mm and 0.62 0.16 mm, p = 0.99). Conclusion: Treatment of hyperhomocysteinemia in chronic hemodialysis patients with daily oral 15 mg folic acid, 50 mg vitamin B6, and 1 mg vitamin B12 for 6 months decreases homocysteine levels and tends to reduce IMT of carotid arteries. A long term study for the prevention of atherosclerosis is warranted. No.1070 Author(s) : Tungsuchat T, Kuroda H, Narangajavana J, Maliga P. Title : Gene activation in plastids by the CRE site – specific recombinase. Source : Plant Molecular Biology. 61 (4 – 5): 711 – 718, 2006 (Jul). Document Type : Article. Keywords : CRE/loxP site – specific recombination, Green fluorescent protein (GFP), Nicotiana tabacum, Plastid gene activation, Plastid transformation. Abstract : We developed a novel system for gene activation in plastids that uses the CRE/loxP site – specific recombination system to create a translatable reading frame by excision of a blocking sequence. To test the system, we introduced an inactive gfp* gene into the tobacco plastid genome downstream of the selectable spectinomcyin resistance (aadA) marker gene. The aadA gene is the blocking sequence, and is flanked by directly oriented loxP sites for excision by the CRE. In the non – activated state, gfp* is transcribed from the aadA promoter, but the mRNA is not translated due to the lack of an AUG translation initiation codon. Green Fluorescent Protein (GFP) expression is activated by excision of the aadA coding segment to link up the gfp* coding region with the translation initiation codon of aadA. Tobacco plants that carry the inactive gfp* gene do not contain detectable levels of GFP. However, activation of gfp* resulted in GFP accumulation, proving the utility of CRE – induced protein expression in tobacco chloroplasts. The gene activation system described here will be useful to probe plastid gene function and for the production of recombinant proteins in chloroplasts. No.1071 Author(s) : Tungtrakanpoung R, Pitaksajjakul P, Na – Ngarm N, Chaicumpa W, Ekpo P, Saengjaruk P, Froman G, Ramasoota P. Title : Mimotope of Leptospira from phage – displayed random peptide library is reactive with both monoclonal antibodies and patients’ sera. Source : Veterinary Microbiology. 115 (1 – 3): 54 – 63, 2006 (Jun). Document Type : Article. Keywords : Phage display, Random peptide library, Mimotope, Monoclonal antibodies, Patients’ sera, Leptospirosis. Abstract : The study aim was to use random heptapeptide library displayed by bacteriophage T7 for identifying mimotopes from 15 monoclonal antibodies (MAbs) specific to Leptospira spp., and from four leptospirosis patient sera, respectively. The bound phages, selected from fourth round of bio – parming with each antibody, were cloned by plaque isolation and the binding specificity of individual clones were confirmed by enzyme – linked immunosorbent assay, before being further amplified and checked for phage peptide sequence using PCR and DNA sequencing. All together 150 phages were selected, mimotope from 86 phages (56.6%) were found to match with protein sequences of Leptospira from GenBank database. The predominant mimotopes were mimotope with sequence LTPCD that found in 27.3%, followed by TPCSK (16%), KSKKSS (4%), KTKRXAS (4%), SSKSYR (3.3%), DPNXNSF (3.3%), KSGRC (2.6%), TLINIF (2%), TPCI (2%),1.33% each with mimotopes PKKS, PCNTKXTA, and CTKKK, and one phage each (0.66%) with mimotopes PTFGS, TNSKRK, SKSSRC, RSKRIR, VTNNTP, and CSNXSKR. Interestingly, mimotopes LTPCD, TPCSK, and TPCI were found to react with both MAb and patient’s sera. The matched proteins from GenBank 385
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