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Photonics Driving Economic Growth in Europe - Photonics21

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2. <strong>Photonics</strong> Research and Innovation Challenges<br />

2.3 Life Science & Health<br />

Ma<strong>in</strong> socio-economic challenges addressed<br />

Progress <strong>in</strong> the field of photonic methods<br />

and techniques for Health and Life Sciences<br />

will contribute significantly to solv<strong>in</strong>g several<br />

of the ‘grand challenges’ of our time as de-<br />

f<strong>in</strong>ed <strong>in</strong> the Lund Declaration of July 2009, by<br />

offer<strong>in</strong>g “susta<strong>in</strong>able solutions <strong>in</strong> areas such<br />

as … water and food, age<strong>in</strong>g societies, public<br />

health, pandemics …”.<br />

For most <strong>Europe</strong>an countries, the projected demo-<br />

graphic changes will have drastic consequences for<br />

<strong>Europe</strong>an citizens and their healthcare systems.<br />

For example, the number of people older than 65<br />

years will double by 2030, lead<strong>in</strong>g to a dramatic<br />

growth of age-related diseases <strong>in</strong>clud<strong>in</strong>g Alzheimer’s<br />

disease, cardiac <strong>in</strong>farction, stroke, age<br />

related macular degeneration, diabetes, kidney<br />

failure, osteoarthritis, and cancer. Greater mobility<br />

of the population will result <strong>in</strong> the <strong>in</strong>creased<br />

occurrence of pandemics. Therefore, provid<strong>in</strong>g<br />

adequate health care for all <strong>Europe</strong>an citizens will<br />

require enormous efforts. These challenges can<br />

best be met through breakthroughs <strong>in</strong> and deployment<br />

of Biophotonic technologies, yield<strong>in</strong>g new<br />

cost-effective methods for improved diagnosis and<br />

therapy. These same technologies can also serve to<br />

control water and food quality, thereby reduc<strong>in</strong>g<br />

diseases caused by contam<strong>in</strong>ation.<br />

Major photonics needs<br />

A major step towards tackl<strong>in</strong>g these challenges will<br />

be to focus Biophotonics research and <strong>in</strong>novation<br />

on the development of easy-to-access, m<strong>in</strong>imally<br />

<strong>in</strong>vasive, low-cost screen<strong>in</strong>g methods. These will<br />

be based on photonics po<strong>in</strong>t-of-care methods and<br />

technologies, provid<strong>in</strong>g a risk assessment of age<br />

and life-style related diseases (ideally risks factors<br />

for a comb<strong>in</strong>ation of several diseases would be assessed<br />

simultaneously), thus establish<strong>in</strong>g a reliable<br />

result with<strong>in</strong> m<strong>in</strong>utes.<br />

Detailed <strong>in</strong>vestigation, employ<strong>in</strong>g more advanced<br />

diagnostic methods to locate and precisely evaluate<br />

the orig<strong>in</strong> of the disease, would then be undertaken<br />

if the screen<strong>in</strong>g returned a positive result for one of<br />

the disease parameters. Improved diagnostic and<br />

<strong>in</strong>terventional methods will be developed, based<br />

on improved multi-band (X-ray, Ultraviolet, Visible,<br />

Near/Mid/Far IR, Terahertz) photonics, spectroscopic<br />

and endoscopic devices. These should provide more<br />

reliable and precise exam<strong>in</strong>ations than current ‘gold<br />

standard’ methods, without <strong>in</strong>creas<strong>in</strong>g exam<strong>in</strong>ation<br />

costs or duration. An illustrative example is<br />

provided by the diagnosis of bowel cancer, where<br />

the established procedure (white-light colonoscopy)<br />

is neither precise nor sensitive enough to<br />

detect all cancerous lesions, and is considered too<br />

<strong>in</strong>vasive a screen<strong>in</strong>g tool for the majority of the<br />

population. Improved screen<strong>in</strong>g should therefore<br />

<strong>in</strong>dicate where further diagnostics was necessary,<br />

and improved diagnostics could precisely locate and<br />

analyse the disease, before therapeutic measures<br />

were <strong>in</strong>itiated. These could <strong>in</strong>corporate multi-band<br />

photonics techniques to provide safer, personalised<br />

treatment methods, tailored for specific therapy<br />

and treatment monitor<strong>in</strong>g.<br />

In addition to their use for the diagnosis and treatment<br />

of diseases, multi-band photonics methods<br />

could also provide preventative tools, for example,<br />

offer<strong>in</strong>g analytical methods to monitor and evalu-<br />

Breakthroughs <strong>in</strong> and<br />

deployment of Biophotonic<br />

technologies will yield<br />

new cost-effective methods<br />

for improved diagnosis<br />

and therapy.<br />

The trend towards an age<strong>in</strong>g<br />

society <strong>in</strong> <strong>Europe</strong> will <strong>in</strong>crease<br />

over the decades. © Fotolia<br />

41

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