Repeated-dose 90-day Oral Toxicity Studies on Whole ... - Europabio

1. Toxicological endpoints
for power calculations
• The MTD has also been defined as the <strong>dose</strong>
that, “…does not produce mortality, clinical
signs of toxicity, or pathologic lesions…”
(Dorato et al., 2008; Sontag, 1976).
• Hence, it is a <strong>dose</strong> that elicits signs more
subtle than overt toxicity.
• Endpoints and effect sizes are taken from the
indicated guidance documents.
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