Repeated-dose 90-day Oral Toxicity Studies on Whole ... - Europabio
Repeated-dose 90-day Oral Toxicity Studies on Whole ... - Europabio
Repeated-dose 90-day Oral Toxicity Studies on Whole ... - Europabio
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4. Results<br />
2 animals/cage, 4 treatment groups, 5 replicate cages/group;<br />
GM vs. n<strong>on</strong>-GM averaged over incorporati<strong>on</strong> rates<br />
Endpoint Effect Size<br />
Predicted Power<br />
Males Females<br />
Body weight 10% 99% 99%<br />
Liver weight 25% >99% >99%<br />
Kidney weight 25% >99% >99%<br />
Leukocyte count 30% 97% 87%<br />
Lymphocyte count 30% 94% 83%<br />
Cholesterol 200% >99% >99%<br />
Blood urea nitrogen 50% >99% >99%<br />
Creatinine 50% >99% >99%<br />
Alkaline phosphatase 100% >99% >99%<br />
35