Repeated-dose 90-day Oral Toxicity Studies on Whole ... - Europabio

4. Results
2 animals/cage, 3 treatment groups, 6 replicate
cages/group; individual treatment comparisons
Endpoint Effect Size
Predicted Power
Males Females
Body weight 10% 91% 91%
Liver weight 25% >99% >99%
Kidney weight 25% >99% >99%
Leukocyte count 30% 83% 67%
Lymphocyte count 30% 77% 61%
Cholesterol 200% >99% >99%
Blood urea nitrogen 50% >99% >99%
Creatinine 50% >99% >99%
Alkaline phosphatase 100% >99% >99%
33