Repeated-dose 90-day Oral Toxicity Studies on Whole ... - Europabio

3. Group or single housing
(continued)
• While the analysis can be done in this way, the majority of
EuropaBio statisticians believe it is more appropriate to
conduct tests of main effects at the cage level regardless of
whether the cage effect is significant or not (in which case
testing the significance of the cage effect is unnecessary).
• EuropaBio members seek assurance that the statement
“statistical analysis can be based on the individual animals” is
not prescriptive and that an approach in which main effects are
always tested at the cage level is acceptable.
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