Repeated-dose 90-day Oral Toxicity Studies on Whole ... - Europabio
Repeated-dose 90-day Oral Toxicity Studies on Whole ... - Europabio
Repeated-dose 90-day Oral Toxicity Studies on Whole ... - Europabio
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4. Endpoints and effect<br />
sizes<br />
Endpoint Change relative to c<strong>on</strong>trol<br />
Body weight Decrease 10%<br />
Liver weight Increase 25%<br />
Kidney weight Increase 25%<br />
Leukocyte count Decrease/increase 30%<br />
Lymphocyte count Decrease/increase 30%<br />
Cholesterol Increase 200%<br />
Blood urea nitrogen Increase 50%<br />
Creatinine Increase 50%<br />
Alkaline phosphatase Increase 200%<br />
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