Repeated-dose 90-day Oral Toxicity Studies on Whole ... - Europabio
Repeated-dose 90-day Oral Toxicity Studies on Whole ... - Europabio
Repeated-dose 90-day Oral Toxicity Studies on Whole ... - Europabio
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2. Experimental design<br />
• EFSA guidance advocates use of a randomised complete block<br />
design (RCBD) in which males and females are randomised<br />
together.<br />
• However, current toxicology study animal husbandry practices<br />
intenti<strong>on</strong>ally separate males and females (e.g., by assigning<br />
genders to different cage racks).<br />
• There is a c<strong>on</strong>cern that housing opposite genders in adjacent<br />
cages, particularly in paired housing setups, may lead to intra-<br />
MSK2 MSK3<br />
cage aggressi<strong>on</strong> in males.<br />
• EuropaBio Members’ str<strong>on</strong>g recommendati<strong>on</strong> is that the<br />
current practice of gender separati<strong>on</strong> be maintained.<br />
17
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