Repeated-dose 90-day Oral Toxicity Studies on Whole ... - Europabio

4. Provisos for power
analyses
• Power investigation for 3-treatment group scenario
comparing control with mean of high and low <strong>dose</strong>s
assumes that, in reality, mean of low <strong>dose</strong> = mean
of high <strong>dose</strong>.
• Power investigation for the 4-treatment group
design assumes that there is no interaction between
treatment (i.e. GM vs. non-GM) and incorporation
rate.
– Analysis of previous data indicates that this
assumption should typically hold in practice.
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