European Human Genetics Conference 2007 June 16 – 19, 2007 ...

Concurrent Sessions
clude plague epidemics, childhood infections or random genetic drift.
Materials and methods. We sampled 1001 examinees from 9 isolated
Dalmatian villages which had differing history of epidemics during the
period between 11th-20th centuries. The demographic history of these
isolates during the past 1,000 years was reconstructed in great detail
from historic records. The frequency of CCR5del32 mutation was determined
in each population.
Results: CCR5del32 mutation frequency in the Croatian general
population is 7.1%. The villages with no history of epidemics had a
CCR5del32 mutation frequency between 1.5% and 3.9% (p