European Human Genetics Conference 2007 June 16 – 19, 2007 ...

Genomics, technology, bioinformatics
on the inhibitory effect of terfernadine on calcium channel, besides
its well-known effect on HERG channel. Further investigation on the
inhibitory effect of terfenadine might help elucidating the mechanism of
cardiac adverse effect caused by some antihistamine drugs.
P1269. Impact of arachidonic acid and moderate and high
docosahexaenoic acid formulas on hepatic gene expression
profiles in baboon neonates
K. S. D. Kothapalli 1 , J. C. Anthony 2 , B. S. Pan 1 , A. T. Hsieh 1 , P. W. Nathanielsz
3 , J. T. Brenna 1 ;
1 Cornell University, Ithaca, NY, United States, 2 Mead Johnson and Company,
Evansville, IN, United States, 3 University of Texas Health Science Center, San
Antonio, TX, United States.
Long chain polyunsaturated fatty acids (LCPUFA), DHA and ARA,
are recent dietary components in infant milk formula but vary in concentration
because optimal levels have not yet been established. In
this study, we utilized high-density Affymetrix oligonucleotide arrays
(“U133 plus 2.0” with >54,000 probesets) to monitor changes in hepatic
mRNA expression levels in baboon neonates, supplemented for
twelve weeks with DHA at two levels (0.33% and 1.0%) and ARA at
one level (0.67%). Twelve baboon neonates were randomized into
three groups (n=4 per group): Control (C, no DHA-ARA); 1 x DHA
(L, 0.33% DHA-0.67% ARA); 3 x DHA (L3, 1.00% DHA-0.67% ARA).
Significance analysis (P