European Human Genetics Conference 2007 June 16 – 19, 2007 ...

Genetic analysis, linkage, and association
women group more than 5 times exceeded these ones in the control
(30% and 6,5% respectively). Alleles and genotypes frequences
for polymorphisms of CC16, NOS1, IL4 & IL4R in ABA group were
found within control limits. 22% of newborns from ABA women had no
adverse genotypes or alleles for GSTM1,GSTT1,IL-4 or IL4R(Q576),
(C590), while 43% of newborns possessed at least 3-4 unfavorable (
ABA predictive) genotypes or alleles and they were enrolled in ABA-
prone group. So far chronic atopic dermatites and other manifestations
of allergy were registered in 83% and 50% respectively of newborns
from the ABA high-risk group and these complications were twice more
often in this group when compared to the ABA-mother born childs without
obvious genetic predisposition. Genetic testing of childs or could
be now efficiently implemented for more sophisticated presymptomatic
selection of individuals with elevated inborn risk of ABA.
P0920. Impact of ACE (Ins/Del), ApoB (R3500Q) and ApoE (E2/
E3/E4) polymorphisms on myocardial perfusion: correlation
with myocardial single photon emission computed tomographic
imaging
G. Wozniak 1,2 , M. Samara 2 , P. Georgoulias 1 , I. Chiotoglou 2 , A. Kontos 1 , V. Valotassiou
1 , P. Kollia 2 ;
1 Department of Nuclear Medicine, School of Medicine, University of Thessaly,
Larissa, Greece, 2 Laboratory of Medical Genetics and Cytogenetics, School of
Medicine, University of Thessaly, Larissa, Greece.
Coronary artery disease (CAD) is associated with multiple genetic and
environmental risk factors, whose cumulative effects have been the focus
of intensive research. Several studies have shown an association
between CAD and polymorphisms in genes implicated in the control of
blood pressure and lipid metabolism. We studied 182 CAD patients with
exercise-rest Tc-99m tetrofosmin myocardial perfusion single photon
emission computed tomography (SPECT) and calculated the summed
stress score (SSS), summed rest score (SRS) and summed difference
score (SDS) indexes. Genetic analysis for ACE (Ins/Del), ApoB
(R3500Q) and ApoE (E2/E3/E4) polymorphisms were determined by
polymerase chain reaction (PCR) and RFLP analysis on agarose gel
electrophoresis. A significant correlation (p