European Human Genetics Conference 2007 June 16 – 19, 2007 ...

Normal variation, population genetics, genetic epidemiology
SG (African/European=79%/21%, R2=0.983) and BR (68%/32%,
R2=0.989). These results are not in agreement to demographic history
and previous studies showing tri-hybrid admixture, which may be explained
by the different nature of markers analyzed. On the other hand,
those associations were not observed in VAL, probably due to its isolation
and no recent admixture. The coefficient of local inbreeding (Fis=-
0,136, p C promoter polymorphism
have lower promoter activity and result in decreased COX-2 expression.
Also, it is reported that this type of polymorphism may have
important role in increased risk of several types of cancers. In addition,
genetic polymorphisms of COX-2 gene could alter enzyme expression
and the response to Nonsteroidal anti-inflammatory drugs (NSAIDs).
In this investigation, we assessed allele frequency of COX-2 polymorphism
among different Iranian populations. The genetic polymorphisms
of COX-2 -765G > C promoter has not been reported among
the Iranian population so far. We initiated a study to examine COX-2
-765G > C promoter genotype in different Iranian ethnic groups. The
samples were collected from healthy population from three different
ethnicity groups (Fars, Turk and Rashti). We assessed the genotype
patterns of COX-2 among Iranian Fars, Turk and Rashti ethnic groups
in five regions. The COX-2 -765G > C promoter genotypes were determined
by polymerase chain reaction-restriction fragment length
polymorphisms (PCR-RFLP) analysis in 90 Iranian healthy individuals.
Allele frequency of COX-2 -765G > C promoter for above populations
were similar and the G allele was significantly higher than C allele.
P1143. Genetic polymorphisms associated with cardiovascular
disease in the Azorean population
P. A. S. Sousa1 , A. R. Couto1 , S. Nemeth2 , J. P. O. Pinheiro1 , C. Oberkanins2 , J.
Bruges-Armas1 ;
1 2 SEEBMO, Angra do Heroísmo, Portugal, ViennaLab Diagnostics GmbH, Vienna,
Austria.
Background: Research on cardiovascular disease (CVD) has revealed
several candidate genes associated with the worlds first cause of dis-
2