DEPARTAMENTO DE CIÊNCIAS DA VIDA ... - Estudo Geral

13
Figure 2 - Proteins related to the mechanosensory in Integrin-Mediated Rigidity Sensing. The yellow boxes
highlight the proteins wich bind directly to the depicted domains. (A) FAK activity is regulated by mechanical
force but does not bind integrins or actin directly. (B) Stretching the p130Cas domain exposes its 15 tyrosine
residues. (C) Stretching of talin’s rod domain exposes vinculin binding sites (del Rio et al., 2009). (D) Extension of
filamin immunoglobulin repeats (labeled 1–24) has been shown by AFM (Furuike et al., 2001) and could regulate
the binding of proteins. (E) a-actinin forms antiparallel dimers; mechanical force could regulate this dimerization
or its association with other proteins. Adapted from Moore et al., 2010.