European Society of Mycobacteriology - Instituto Nacional de Saúde ...

PP-51
Nontuberculous Mycobacteria, isolated from patients with
lung disease, from Lisboa e Vale do Tejo region, during 2008
António Amorim 1* , Rita Macedo, Edna Pereira
Laboratório de Saúde Pública - Micobacteriologia/Tuberculose, Administração Regional de Saúde de Lisboa e Vale do Tejo,
I.P., Lisboa, Portugal
*
Presenting author. Phone: 00351213602520. E-mail address: antonio.amorim@csalcantara.min-saude.pt
Despite the clinical relevance of most nontuberculous mycobacteria (NMT) in pulmonary infection in immunocompetent
patients is still unclear, this mycobacteria play an increasing significant pathogenic role in HIV-positive, and other immunocompromised
patients. Nevertheless, no data about NTM species isolated from patients with lung disease, from Lisboa e
Vale do Tejo region, are published or available until now.
We carried out a study during the entire year of 2008 with the purpose of identify, determine the incidence of each
specie, and correlate this data with some epidemiological data in patients with lung disease from Lisboa e Vale do Tejo region.
A total of 46 patients with lung disease were detected with NTM infection. Among this patients the isolated nontuberculous
mycobacteria were M. intracellulare (n=7, 15,2%), M. fortuitum (n=6, 13%), M. kansassi (n=6, 13%), M. chelonae (n=4,
8,7%), M. gordonae (n=4, 8,7%), M. avium (n=3, 6,6%), M. peregrinum (n=3, 6,6%), M. spp (n=3, 6,6%), M. abscessus (n=2,
4,3%), M. mucogenicum (n=2, 4,3%), M. szulgai (n=2, 4,3%), M. triplex (n=2, 4,3%), M. lentiflavum (n=1, 2,2%) and M. simiae
(n=1, 2,2%). The patients with lung disease that we identified as infected with NMT have a median age of 51,6 years, 45,7%
(21/46) were male and 54,3% (25/46)were female. Despite 43,5% (20/46) of our patients were HIV-state unknown, in the
group of known HIV-state, 88,5% (23/26) were HIV-negative, and only 11,5% (3/26) were HIV-positive.
Our results suggest that the pattern of NTM pulmonary infection, in Lisboa e Vale do Tejo, has no significant differences
from those reported in the rest of Europe and USA, and also, no significant correlation with HIV status. We carried out
the study during only one year, so, further studies are needed to better clarify the NMT infection in patients with lung
disease, in Portugal, in both immunocompromised and immunocompetent patients.
European Society of Mycobacteriology | 30 th Annual Congress | July 2009 | Porto - Portugal
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