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PP-3 ASSOCIATION BETWEEN BEIJING GENOTYPE AND DRUG RESISTANCE AMONG Mycobacterium tuberculosis ISOLATES CIRCULATING IN THE REPUBLIC OF GEORGIA Stefan Niemann 1 , G. Khechinashvili 2 , M. Gegia 2 , N. Mdivani 2 , and Y. W. Tang 3 Molecular Mycobacteriology, National Reference Center for Mycobacteria, Research Center Borstel, Borstel, Germany Georgian Foundation against Tuberculosis and Lung Diseases, Tbilisi, Georgia Vanderbilt University Medical Center, Nashville, TN, USA Rising tuberculosis (TB) rates and high levels of multidrug-resistant TB (MDR-TB) have become a major public health problem in several parts of the former Soviet Union. High rates and transmission of MDR-TB have been noticed to be associated with the presence of Mycobacterium tuberculosis Beijing genotype strains pointing to the importance of pathogen genetic factors for the modulation of infection outcome and epidemiology. Here we present the first data on the population structure of M. tuberculosis strains from the Republic of Georgia, a high incidence setting at the Black Sea Coast. All strains were analysed by spoligotyping and 24-loci MIRU-VNTR genotyping. Identification of major M. tuberculosis genotypes was carried out by using the MIRU-VNTRPlus database (www.miru-vntrplus.org) and a similarity analysis performed to identify strains with identical genotyping profiles (clusters), which are indicative for the rate of recent transmission. Anti-tuberculosis drug resistance was determined by in vitro antimicrobial susceptibility testing. Genotyping profiles were successfully generated for 187 M. tuberculosis isolates which were further investigated. The most prominent genotype found, was Beijing (29%), followed by LAM (18%), Ural (12%), and Haarlem (n=10) strains. Approx 50% of the isolates were grouped in clusters. When the distribution of drug resistance is considered, it was noticed that MDR-TB was nearly completely restricted to Beijing strains. Further detailed analyses are currently in progress. Our data underline the importance of Beijing genotype strains for the TB epidemiology in former Soviet Union countries. However, Ural, Haarlem genotype and a large variety of strains of so far undefined lineages represent nearly two third of the strains found in Georgia. Although Beijing strains are not as dominant as in others Eastern European countries such as Kazakhstan, we confirm a clear association between MDR-TB and the Beijing genotype in Republic of Georgia. European Society of Mycobacteriology | 30 th Annual Congress | July 2009 | Porto - Portugal 77
PP-4 Mycobacterium tuberculosis EPIDEMIOLOGY AND GENETIC DIVERSITY IN THE TWIN ISLAND REPUBLIC OF TRINIDAD AND TOBAGO Shirematee Baboolal, 1, 2 Julie Millet, 3 Patrick Eberechi Akpaka, 1 Dottin Ramoutar, 4 Nalin Rastogi 3 1 - Department of Para-Clinical Sciences, Faculty of Medical Sciences, The University of the West Indies, St. Augustine, Trinidad & Tobago 2 - Caribbean Epidemiology Centre, Jamaica Boulevard, Port of Spain, Trinidad & Tobago 3 - Unité de la Tuberculose et des Mycobactéries, Institut Pasteur de Guadeloupe, Abymes, Guadeloupe 4 - Caura Chest Hospital, Caura, Trinidad & Tobago This work describes the first application of molecular tools for studying tuberculosis (TB) epidemiology, genetic diversity, and transmission in the twin island Republic of Trinidad and Tobago (T&T). The study population (n=132) represented one year recruitment of all culture positive TB cases from T&T, and was characterized by a high male to female sex-ratio of 4 (mean age 42.8 years, range 17 to 78 years), and a HIV/TB coinfection rate of nearly 30%. It mainly occurred among African descendants who represented 37.5% of total population but 69.7% of all TB cases (p
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ESM European Society of Mycobacteri
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Welcome Message Dear Colleagues, It
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Congress Organization EUROPEAN SOCI
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Program at a glance Sunday, July 5t
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Wednesday, July 8th 09h00 - 11h00 0
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Dr. Andre De Bock (BD) Extended Dru
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16h30 - 16h45 Santos R, Marques M,
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09h45 - 10h30 10h30 - 10h45 10h45 -
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Mello FAF, Albarral MIP, Mendes NH,
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Lima KVB, Lopes ML, Furlaneto IP, L
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Julián EG, Rodríguez-Güell E, de
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Abstracts of Guest Lectures (GL) Eu
Page 27 and 28: GL-2 THE BRAZILIAN EXPERIENCE CONTR
Page 29 and 30: GL-3 EVOLUTIONARY FORCES IN Mycobac
Page 31 and 32: GL-5 SURROUNDED BY MYCOBACTERIA Jos
Page 33 and 34: GL-7 A NOVEL DIAGNOSTIC TEST TO DIF
Page 35 and 36: GL-9 REGULATION OF Mycobacterium tu
Page 37 and 38: GL-11 DEVELOPMENT AND VALIDATION OF
Page 39 and 40: SCREENING OF MOLECULES WITH ANTI-TB
Page 41 and 42: GL-15 NEW, EASY-TO-USE TOOLS FOR QU
Page 44 and 45: OP-1 Mass Spectrometry for Molecula
Page 46 and 47: OP-3 IDENTIFICATION OF THE INSERTIO
Page 48 and 49: OP-5 PENITENTIARY POPULATION OF Myc
Page 50 and 51: op-7 Mycobacterium tuberculosis gen
Page 52 and 53: OP-9 LAM AND HIV: CORRELATION OR CO
Page 54 and 55: OP-11 Mycobacterium avium SUBSPECIE
Page 56 and 57: OP-13 THE SUNNY SIDE OF MYCOBACTERI
Page 58 and 59: OP-15 HOW WILD-TYPE MIC DISTRIBUTIO
Page 60 and 61: OP-17 Mycobacterium tuberculosis IS
Page 62 and 63: A REPORT ON NEW ADAPTED FORMS OF EX
Page 64 and 65: OP-21 PRESENCE OF ESAT-6 AND CFP-10
Page 66 and 67: OP-23 TUBERCULOSIS SOFTWARE IN A GE
Page 68 and 69: OP-24 Development of an automated c
Page 70 and 71: OP-26 THIORIDAZINE SHOWS PROMISING
Page 72: OP-28 MEMBRANE- BASED VERSUS MICROB
Page 76 and 77: PP-1 EVALUATION OF THE HIGH-THROUGH
Page 80 and 81: PP-6 SPOLIGOTYPE PATTERNS AND DRUG
Page 82 and 83: PP-8 Mycobacterium tuberculosis BEI
Page 84 and 85: PP-11 FITNESS STUDY OF THE RD RIO L
Page 86 and 87: PP-13 IMPORTANCE OF MOLECULAR TYPIN
Page 88 and 89: PP-15 MOLECULAR EPIDEMIOLOGY STUDY
Page 90 and 91: SPOLIGOTYPING OF Mycobacterium tube
Page 92 and 93: PP-19 MULTIPLY RECURRENT TUBERCULOS
Page 94 and 95: PP-21 MOLECULAR STUDY OF RECURRENT
Page 96 and 97: GENOTYPING OF MONO AND MULTI-DRUG R
Page 98 and 99: PP-25 Drug-resistance of Mycobacter
Page 100 and 101: PP-27 Mutational analysis of genes
Page 102 and 103: PP-29 CHARACTERISATION OF STREPTOMY
Page 104 and 105: PP-31 tuberculosis RESISTANCE in a
Page 106 and 107: PP-33 GENOTYPIC DETECTION OF ISONIA
Page 108 and 109: PP-35 Mycobacterium tuberculosis: 1
Page 110 and 111: PP-37 IN VITRO ACTIVITY OF OFLOXACI
Page 112 and 113: DETECTION OF EMBB GENE CODON 306 MU
Page 114 and 115: PP-41 Characterization of gidB gene
Page 116 and 117: PP-43 DESIGN OF A RAPID METHOD OF I
Page 118 and 119: PP-45 Resistance, MDR and XDR of M.
Page 120 and 121: PP-47 TYPING OF Mycobacterium avium
Page 122 and 123: PP-49 IS1245-RFLP Based Genetic Rel
Page 124 and 125: PP-51 Nontuberculous Mycobacteria,
Page 126 and 127: PP-53 EVALUATION OF HSP 65, TB ,SP
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IDENTIFICATION OF NONTUBERCULOUS MY
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PP-57 ISOLATION AND IDENTIFICATION
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PP-59 A CASE-REPORT OF Mycobacteriu
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PP-61 LABORATORY MICROBIOLOGY CONTR
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TEACHING OLD BONES NEW TRICKS; SING
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DIRECT IDENTIFICATION OF Mycobacter
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PP-67 FIRST EXPERIENCE WITH GENOTYP
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PP-69 EVALUATION OF A NEW REAL-TIME
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CLINICAL PERFORMANCE OF QUANTIFERON
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PP-73 QUANTIFERON ® -TB GOLD IN-TU
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REAL-TIME POLYMERASE CHAIN REACTION
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PP-77 DETECTION OF Mycobacterium tu
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PP-79 OSSEOUS TUBERCULOSIS AT AGE O
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PP-81 ROLE OF TNF-a GENE POLYMORPHI
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PP-83 VIRULENCE, IMMUNOGENICITY AND
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PP-85 ANALYSIS OF M. smegmatis MUTA
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PP-87 Mycobacterium tuberculosis Ar
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IMPLEMENTATION OF THE THIN LAYER AG
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PP-91 DIRECT DETECTION OF RIFAMPIN
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PP-93 CONTRIBUTION OF LABORATORY FA
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PP-95 EVALUATION OF CAPILIA (TAUNS)
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PP-97 DIRECT TESTING FOR MULTI DRUG
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PP-99 VARIOUS STRATEGIES TO DECONTA
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PP-101 COMPARISON OF RAPID COLORIME
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PP-103 NITRATE REDUCTASE ASSAY APPL
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PP-105 Implementation of liquid cul
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PP-107 SYNERGISTIC ACTIVITY OF TWO
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PP-109 PREVALENCE OF EFFLUX-MEDIATE
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PP-111 ANTI-MYCOBACTERIUM TUBERCULO
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PP-113 the human macrophage as a mo
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PP-115 Nosocomial TB in a laborator
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Levterova V Lezcano MA Lima EJC Lim
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