Transmucosal Nasal Drug Delivery: Systemic Bioavailability of ...

10 Appendix
10.2.3 Accelerated stability testing: Preparation 4 (30 mg/ml)
day
room temperature 40°C 50°C 60°C
concentration content concentration content concentration content concentration content
[mg/ml] [%] [mg/ml] [%] [mg/ml] [%] [mg/ml] [%]
0 30.0 100 30.0 100 30.0 100 30.0 100
3 30.0 100 29.6 99 30.6 102 30.6 102
6 29.3 98 27.7 92 29.7 99 29.5 98
9 30.6 102 30.5 102 30.0 100 30.1 100
12 29.8 99 29.7 99 30.8 103 30.1 100
15 29.7 99 30.5 102 29.5 98 29.5 98
18 30.1 100 30.7 102 30.1 100 30.3 101
21 30.7 102 30.0 100 30.3 101 29.9 100
24 30.5 102 30.3 101 30.2 101 30.4 101
27 30.2 101 30.6 102 30.3 101 29.8 99
30 30.2 101 30.2 101 30.8 103 30.4 101
room temperature 40°C 50°C 60°C
Tage pH color precipitation pH color precipitation pH color precipitation pH color precipitation
0 3.7 colorless no 3.7 colorless no 3.7 colorless no 3.7 colorless no
3 3.7 colorless no 3.7 colorless no 3.7 colorless no 3.7 colorless no
6 3.7 colorless no 3.7 colorless no 3.7 colorless no 3.7 colorless no
9 3.7 colorless no 3.7 colorless no 3.7 yellowish no 3.7 yellowish no
12 3.7 colorless no 3.7 colorless no 3.7 yellowish no 3.7 yellowish no
15 3.7 colorless no 3.7 colorless no 3.7 yellowish no 3.7 yellowish no
18 3.7 colorless no 3.7 colorless no 3.7 yellowish no 3.7 yellowish no
21 3.7 colorless no 3.7 colorless no 3.7 yellowish no 3.7 yellowish no
24 3.7 colorless no 3.7 colorless no 3.7 yellowish no 3.7 yellowish no
27 3.7 colorless no 3.7 colorless no 3.7 yellowish no 3.6 yellowish no
30 3.7 colorless no 3.7 colorless no 3.7 yellowish no 3.7 yellowish no
Katja Suter-Zimmermann Page 107 of 188 University of Basel, 2008