Transmucosal Nasal Drug Delivery: Systemic Bioavailability of ...

10 Appendix
10.3.8 Midazolam serum concentration time profiles (all subjects)
100
1mg midazolam nasal
90
(Preparation 1)
80
70
60
50
40
Midazolam serum concentration [ug/ml
30
20
10
0
-10 40 90 140 190 240 290 340 390
100
90
80
70
60
50
40
30
20
10
1mg midazolam nasal
(Preparation 2)
0
-10 40 90 140 190 240 290 340 390
100
1mg midazolam nasal
90
(Preparation 3)
100
1mg midazolam i.v.
90
(Dormicum)
80
70
60
50
40
30
20
10
0
-10 40 90 140 190 240 290 340 390
100
3mg midazolam nasal
90
(Preparation 4)
80
70
60
50
40
30
20
10
0
-10 40 90 140 190 240 290 340 390
100
3mg midazolam nasal
90
(Preparation 5)
80
70
60
50
40
30
20
10
80
70
60
50
40
30
20
10
0
-10 40 90 140 190 240 290 340 390
Time [min]
0
-10 40 90 140 190 240 290 340 390
Figure 10-3: Overlayed midazolam serum concentration time profile after i.v. and nasal administration
of 1 mg midazolam (Dormicum ® and Preparation 1, 2, and 3), nasal administration of 3 mg
(Preparation 4 and 5) to 8 healthy volunteers.
Katja Suter-Zimmermann Page 160 of 188 University of Basel, 2008