Transmucosal Nasal Drug Delivery: Systemic Bioavailability of ...

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Genehmigt von der Philosophisch-Naturwissenschaftlichen Fakultät Auf Antrag von Prof. Dr. phil. Christian Surber Prof. Dr. phil. Georgios Imanidis Prof. Dr. phil. Hans Leuenberger Basel, den 22. Mai 2007 Prof. Dr. phil. Hans-Peter Hauri Dekan
Page 1: TRANSMUCOSAL NASAL DRUG DELIVERY Sy
Page 6 and 7: Index 1 Index Abbreviations .......
Page 9: Abbreviations Abbreviations ACN CD
Page 12 and 13: Summary Project II: Pharmacokinetic
Page 15: Background and objectives Backgroun
Page 19 and 20: 1. Nasal drug delivery 1 Nasal drug
Page 21 and 22: 1. Nasal drug delivery Table 1-1: C
Page 23: 1. Nasal drug delivery 1.4 Nose to
Page 26 and 27: 2. Impact of anatomy and physiology
Page 32 and 33: 3. Midazolam 3.2 Pharmacologic effe
Page 34 and 35: 3. Midazolam 3.2.2 Conscious sedati
Page 36 and 37: 3. Midazolam Table 3-2: Benefits an
Page 38 and 39: 3. Midazolam Table 3-4: Indications
Page 40 and 41: 4. Compounding of nasal midazolam p
Page 51: EXPERIMENTAL SECTION
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5. Project I: Development of prepar
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6. Project II: Pharmacokinetic of t
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7. Project III: Transmucosal nasal
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8 Overall discussion 8 Overall disc
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8 Overall discussion unusual applic
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8 Overall discussion 9 Final conclu
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10 Appendix 10.1.1 Pharmacokinetic
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10 Appendix 10.2.3 Accelerated stab
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10 Appendix 10.2.5 Specification: M
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10 Appendix 10.2.7 Specification: C
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10 Appendix 10.2.8 Specification: C
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10 Appendix 10.2.10 Stability repor
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10 Appendix Project II 10.3.1 Study
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10 Appendix Katja Suter-Zimmermann
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10 Appendix 1.3.3 Case report form:
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10 Appendix Frequency 10.3.6 Intens
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10 Appendix Identification midazola
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10 Appendix 10.3.9 Nasal delivery o
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10 Appendix 10.4. Project III 10.4.
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10 Appendix 10.4.4 Instruction mate
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11 References Cote, C.J., Md, I.T.
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11 References Griffith, N., S. Howe
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11 References Lahat, E., M. Goldman
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11 References Mygind, N. and R. Dah
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11 References Tschirch, F.T., K. Go
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12 Curriculum vitae During my acade
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