Transmucosal Nasal Drug Delivery: Systemic Bioavailability of ...

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10 Appendix Frequency 10.3.5 Intensity of local irritation after nasal administration of 1 mg 8 7 6 5 4 3 2 1 0 very slight slight intermediate strong very strong very slight slight intermediate strong Preparation 1 very strong very slight slight intermediate strong very strong very slight slight intermediate strong very strong very slight nose slight intermediate throat strong very strong administration 5 min 15 min 30 min 4 h Frequency 8 7 6 5 4 3 2 1 0 Preparation 2 very slight slight intermediate strong very strong very slight slight intermediate strong very strong very slight slight intermediate strong very strong very slight slight intermediate strong very strong very slight slight intermediate strong very strong nose throat administration 5 min 15 min 30 min 4 h Frequency 8 7 6 5 4 3 2 1 0 Preparation 3 very slight slight intermediate strong very strong very slight slight intermediate strong very strong very slight slight intermediate strong very strong very slight slight intermediate strong very strong very slight slight intermediate strong very strong nose throat Applikation 5 Minuten 15 Minuten 30 Minuten 4 Stunden Figure 10-1: Intensity of local irritation (nose and throat area) after nasal administration of Preparation 1, 2 and 3 (1 mg midazolam), immediately after administration, 5 min, 15 min, 30 min, and 4 h after nasal administration Katja Suter-Zimmermann Page 150 of 188 University of Basel, 2008
10 Appendix Frequency 10.3.6 Intensity of local irritation after nasal administration of 3 mg 8 7 6 5 4 3 2 1 0 very slight slight intermediate strong very strong very slight slight intermediate strong Preparation 4 very strong very slight slight intermediate strong very strong very slight slight intermediate strong very strong very slight nose slight intermediate throat strong very strong administration 5 min 15 min 30 min 4 h Frequency 8 7 6 5 4 3 2 1 0 Preparation 5 very slight slight intermediate strong very strong very slight slight intermediate strong very strong very slight slight intermediate strong very strong very slight slight intermediate strong very strong very slight slight intermediate strong very strong nose throat administration 5 min 15 min 30 min 4 h Figure 10-2: Intensity of local irritation (nose and throat area) after nasal administration of Preparation 4 and 5 (3 mg midazolam), immediately after administration, 5 min, 15 min, 30 min, and 4 h after nasal administration Katja Suter-Zimmermann Page 151 of 188 University of Basel, 2008
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TRANSMUCOSAL NASAL DRUG DELIVERY Sy
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Acknowledgments At the Hospital Pha
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Index EXPERIMENTAL SECTION 5 Projec
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Summary Summary Transmucosal nasal
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Summary Project III: In this random
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THEORETICAL SECTION
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1. Nasal drug delivery 1.2 Transmuc
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1. Nasal drug delivery 1.3 Challeng
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2. Impact of anatomy and physiology
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3. Midazolam 3 Midazolam 3.1 Physic
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3. Midazolam 3.2.1 Indications and
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3. Midazolam Administration of high
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3. Midazolam gastrointestinal tract
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4. Compounding of nasal midazolam p
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5. Project I: Development of prepar
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6. Project II: Pharmacokinetic of t
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7. Project III: Transmucosal nasal
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8 Overall discussion pharmacokineti
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Page 114 and 115: 10 Appendix 10.2 Project I 10.2.1 R
Page 116 and 117: 10 Appendix 10.2.4 Specification: M
Page 118 and 119: 10 Appendix 10.2.6 Specification: C
Page 120 and 121: 10 Appendix Katja Suter-Zimmermann
Page 122 and 123: 10 Appendix 10.2.9 Specification: C
Page 150 and 151: 10 Appendix 10.3.2 Case report form
Page 160 and 161: 10 Appendix 10.3.7 Serumconcentrati
Page 162 and 163: 10 Appendix Identification midazola
Page 168 and 169: 10 Appendix 10.3.8 Midazolam serum
Page 170 and 171: 10 Appendix 10.3.10 Nasal delivery
Page 174 and 175: 10 Appendix 10.4.3 Flowchart: multi
Page 185 and 186: 11 References 11 References Abrams,
Page 187 and 188: 11 References Erjefalt, J.S., I. Er
Page 189 and 190: 11 References Irie, T. and K. Uekam
Page 191 and 192: 11 References Malinovsky, J.M., C.
Page 193 and 194: 11 References Scheepers, M., B. Sch
Page 195 and 196: 12 Curriculum vitae 12 Curriculum v
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