Transmucosal Nasal Drug Delivery: Systemic Bioavailability of ...
Transmucosal Nasal Drug Delivery: Systemic Bioavailability of ...
Transmucosal Nasal Drug Delivery: Systemic Bioavailability of ...
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10 Appendix<br />
Frequency<br />
10.3.5 Intensity <strong>of</strong> local irritation after nasal administration <strong>of</strong> 1 mg<br />
8<br />
7<br />
6<br />
5<br />
4<br />
3<br />
2<br />
1<br />
0<br />
very slight<br />
slight<br />
intermediate<br />
strong<br />
very strong<br />
very slight<br />
slight<br />
intermediate<br />
strong<br />
Preparation 1<br />
very strong<br />
very slight<br />
slight<br />
intermediate<br />
strong<br />
very strong<br />
very slight<br />
slight<br />
intermediate<br />
strong<br />
very strong<br />
very slight<br />
nose<br />
slight<br />
intermediate<br />
throat<br />
strong<br />
very strong<br />
administration 5 min 15 min 30 min 4 h<br />
Frequency<br />
8<br />
7<br />
6<br />
5<br />
4<br />
3<br />
2<br />
1<br />
0<br />
Preparation 2<br />
very slight<br />
slight<br />
intermediate<br />
strong<br />
very strong<br />
very slight<br />
slight<br />
intermediate<br />
strong<br />
very strong<br />
very slight<br />
slight<br />
intermediate<br />
strong<br />
very strong<br />
very slight<br />
slight<br />
intermediate<br />
strong<br />
very strong<br />
very slight<br />
slight<br />
intermediate<br />
strong<br />
very strong<br />
nose<br />
throat<br />
administration 5 min 15 min 30 min 4 h<br />
Frequency<br />
8<br />
7<br />
6<br />
5<br />
4<br />
3<br />
2<br />
1<br />
0<br />
Preparation 3<br />
very slight<br />
slight<br />
intermediate<br />
strong<br />
very strong<br />
very slight<br />
slight<br />
intermediate<br />
strong<br />
very strong<br />
very slight<br />
slight<br />
intermediate<br />
strong<br />
very strong<br />
very slight<br />
slight<br />
intermediate<br />
strong<br />
very strong<br />
very slight<br />
slight<br />
intermediate<br />
strong<br />
very strong<br />
nose<br />
throat<br />
Applikation 5 Minuten 15 Minuten 30 Minuten 4 Stunden<br />
Figure 10-1: Intensity <strong>of</strong> local irritation (nose and throat area) after nasal administration <strong>of</strong><br />
Preparation 1, 2 and 3 (1 mg midazolam), immediately after administration, 5 min, 15 min, 30 min, and<br />
4 h after nasal administration<br />
Katja Suter-Zimmermann Page 150 <strong>of</strong> 188 University <strong>of</strong> Basel, 2008