Transmucosal Nasal Drug Delivery: Systemic Bioavailability of ...

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10 Appendix Identification midazolam [ug/L] α-hy-midazolam [ug/L] 4-hy-midazolam [ug/L] Identification midazolam [ug/L] α-hy-midazolam [ug/L] 4-hy-midazolam [ug/L] 9-V2-t0 nn nn nn 9-V3-t0 nn nn nn 9-V2-t1 2.5 nn nn 9-V3-t1 nn nn nn 9-V2-t2 25.7 nn nn 9-V3-t2 8.1 nn nn 9-V2-t3 22.3 nn nn 9-V3-t3 19.7 nn nn 9-V2-t4 16.4 0.3 nn 9-V3-t4 16.3 nn nn 9-V2-t5 15.1 0.6 nn 9-V3-t5 18.6 0.2 nn 9-V2-t6 14.3 1 nn 9-V3-t6 16.7 0.5 nn 9-V2-t7 12.7 1.2
10 Appendix Identification midazolam [ug/L] α-hy-midazolam [ug/L] 4-hy-midazolam [ug/L] Identification midazolam [ug/L] α-hy-midazolam [ug/L] 4-hy-midazolam [ug/L] 11-V2-t0 nn nn nn 11-V3-t0 nn nn nn 11-V2-t1 42.9 nn nn 11-V3-t1 nn nn nn 11-V2-t2 48.7 nn nn 11-V3-t2 13.2 nn nn 11-V2-t3 32 nn nn 11-V3-t3 26.5 nn nn 11-V2-t4 18.8 0.2 nn 11-V3-t4 32.9 nn nn 11-V2-t5 17.3 0.7 nn 11-V3-t5 25.7 0.3 nn 11-V2-t6 14.3 0.9 nn 11-V3-t6 20.7 0.7 nn 11-V2-t7 16.1 1.1
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TRANSMUCOSAL NASAL DRUG DELIVERY Sy
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Acknowledgments At the Hospital Pha
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Index EXPERIMENTAL SECTION 5 Projec
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Summary Summary Transmucosal nasal
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Summary Project III: In this random
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THEORETICAL SECTION
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1. Nasal drug delivery 1.2 Transmuc
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1. Nasal drug delivery 1.3 Challeng
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2. Impact of anatomy and physiology
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3. Midazolam 3 Midazolam 3.1 Physic
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3. Midazolam 3.2.1 Indications and
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3. Midazolam Administration of high
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3. Midazolam gastrointestinal tract
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4. Compounding of nasal midazolam p
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5. Project I: Development of prepar
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6. Project II: Pharmacokinetic of t
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7. Project III: Transmucosal nasal
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8 Overall discussion pharmacokineti
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8 Overall discussion considered as
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Appendix
Page 114 and 115: 10 Appendix 10.2 Project I 10.2.1 R
Page 116 and 117: 10 Appendix 10.2.4 Specification: M
Page 118 and 119: 10 Appendix 10.2.6 Specification: C
Page 120 and 121: 10 Appendix Katja Suter-Zimmermann
Page 122 and 123: 10 Appendix 10.2.9 Specification: C
Page 150 and 151: 10 Appendix 10.3.2 Case report form
Page 158 and 159: 10 Appendix Frequency 10.3.5 Intens
Page 160 and 161: 10 Appendix 10.3.7 Serumconcentrati
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Page 168 and 169: 10 Appendix 10.3.8 Midazolam serum
Page 170 and 171: 10 Appendix 10.3.10 Nasal delivery
Page 174 and 175: 10 Appendix 10.4.3 Flowchart: multi
Page 185 and 186: 11 References 11 References Abrams,
Page 187 and 188: 11 References Erjefalt, J.S., I. Er
Page 189 and 190: 11 References Irie, T. and K. Uekam
Page 191 and 192: 11 References Malinovsky, J.M., C.
Page 193 and 194: 11 References Scheepers, M., B. Sch
Page 195 and 196: 12 Curriculum vitae 12 Curriculum v
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