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NCCR Guide 2013 - Schweizerischer Nationalfonds (SNF)

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Topics<br />

Today, knowledge about<br />

biological processes is<br />

obtained from functional<br />

experiments on a limited<br />

number of biochemical<br />

systems, and from a rapidly<br />

increasing amount of<br />

DNA sequence information,<br />

generated in several<br />

genome projects. To bridge<br />

the widening gap between<br />

rapidly increasing information<br />

on genome sequences<br />

and limited know ledge<br />

on the function of gene<br />

products, a quantitative<br />

understanding of the 3Dstructure<br />

of proteins, their<br />

Heads of Individual Research Projects and Associated Groups<br />

Allain Frédéric, Prof.<br />

Ban Nenad, Prof.<br />

Dutzler Raimund, Prof.<br />

Glockshuber Rudolf, Prof.<br />

Grütter Markus, Prof.<br />

Locher Kaspar, Prof.<br />

Medalia Ohad, Prof.<br />

Plückthun Andreas, Prof.<br />

Richmond Timothy J., Prof.<br />

Schuler Ben, Prof.<br />

Schertler Gebhard, Prof.<br />

Stahlberg Henning, Prof.<br />

van Gunsteren Wilfred F., Prof.<br />

Weber-Ban Erika<br />

Wüthrich Kurt, Prof.<br />

folding, and their interactions<br />

with other molecules<br />

is required. Such<br />

understanding is the key<br />

to develop innovative medi<br />

cines, such as new antibiotics<br />

and vaccines, as<br />

well as drugs against<br />

cancer and diseases of<br />

the central nervous, immune,<br />

and cardiovascular<br />

systems. In this <strong>NCCR</strong><br />

specialists in experimental<br />

struc tu re determination<br />

by X-ray crystallography,<br />

NMR spectroscopy<br />

and electron microscopy<br />

/ crystallo gra phy, in protein<br />

biophysical chemistry,<br />

modern molecular biology,<br />

and computational biology<br />

will meet the challenge to<br />

link the ever increasing biological<br />

data generated in the<br />

genomics field with related<br />

structural and functional<br />

information. This <strong>NCCR</strong> is<br />

currently in its third and<br />

final funding period until<br />

<strong>2013</strong>. The major assets resulting<br />

from this project<br />

will be secured longterm<br />

through the foundation of a<br />

center of structural biology<br />

head-quartered in Zürich.<br />

Institut für Molekularbiologie und Biophysik, ETH Zürich<br />

Institut für Molekularbiologie und Biophysik, ETH Zürich<br />

Institut für Biochemie, Universität Zürich<br />

Institut für Molekularbiologie und Biophysik, ETH Zürich<br />

Institut für Biochemie, Universität Zürich<br />

Institut für Molekularbiologie und Biophysik, ETH Zürich<br />

Institut für Biochemie, Universität Zürich<br />

Institut für Biochemie, Universität Zürich<br />

Institut für Molekularbiologie und Biophysik, ETH Zürich<br />

Institut für Biochemie, Universität Zürich<br />

Paul Scherrer Institut, Villigen PSI<br />

C-CINA, Biozentrum, Universität Basel<br />

Laboratorium für physikalische Chemie, ETH Zürich<br />

Institut für Molekularbiologie und Biophysik, ETH Zürich<br />

Institut für Molekularbiologie und Biophysik, ETH Zürich<br />

Third Party Cooperation<br />

Programmes<br />

• EDICT (FP7)<br />

• P-CUBE (FP7)<br />

Research Institutions<br />

• Biochemistry, Brandeis University,<br />

Waltham, US<br />

• Biozentrum, University of Basel,<br />

Basel, CH<br />

• Cancer Research (CSHL), Cold<br />

Spring Harbour Laboratories, US<br />

• Center for Cellular Imaging<br />

and Nanoanalytics,<br />

University of Basel, CH<br />

• Centre de Regulacio Genomica,<br />

Institució Catalana de Recerca i<br />

Estudis Avançats, Barcelona, ES<br />

• Department Biophysical<br />

Chemistry, Max-Planck-Institute<br />

for Intelligent Systems,<br />

Stuttgart, DE<br />

• Département de Microbiologie<br />

et d’Infectiologie,<br />

Université de Sherbrooke, CA<br />

• Department of Biochemistry,<br />

New York University School of<br />

Medicine, New York, US<br />

• Department of Biochemistry,<br />

University of Washington,<br />

Seattle, US<br />

• Department of Biological Sciences,<br />

University of Illinois, Chicago, US<br />

• Department of Biology,<br />

University of Science and<br />

Technology of China, Hefei, CN<br />

• Department of Biophysical<br />

Structural Chemistry, Leiden<br />

Institute of Chemistry, NL<br />

• Department of Chemistry and<br />

Molecular Biology, University of<br />

Gothenburg, Gothenburg, Sweden<br />

• Department of Chemistry,<br />

Ludwig-Maximilian-University<br />

Munich, DE<br />

• Department of Chemistry,<br />

University of Cambridge, GB<br />

• Department of Chemistry, Wayne<br />

State University, Detroit, US<br />

• Department of Genetics, The<br />

Hebrew University of Jerusalem,<br />

Jerusalem, IL<br />

• Department of Hematology, The<br />

Hebrew University of Jerusalem -<br />

Hadassah Medical Organization,<br />

Jerusalem, IL<br />

• Department of Molecular<br />

Biology and Biotechnology,<br />

University of Sheffield, GB<br />

• Department of Molecular Cell<br />

Biology, Weizmann Institute of<br />

Science, Rehovot, IL<br />

• Department of Molecular<br />

Biophysics and Biochemistry,<br />

Yale University, New Haven, US<br />

• Department of Molecular<br />

Medicine, Max Planck Institute of<br />

Biochemistry, Martinsried, DE<br />

• Department of Pharmacology,<br />

School of Medicine, Cleveland, US<br />

• Department of Physics, University<br />

of California, Santa Barbara, US<br />

• Department of Pharmacology,<br />

University of North Carolina,<br />

Chapel Hill, US<br />

<strong>Guide</strong> <strong>2013</strong> | 17

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