NCCR Guide 2013 - Schweizerischer Nationalfonds (SNF)

From transport physiology
to identification
of therapeutic target
NCCR TransCure
Third Party Cooperation
Programmes
• EUROCORES (ESF)
• IFP TransCure
Research Institutions
• Cellular Neuroscience, Max
Delbruck Center for Molecular
Medicine, Berlin-Buch, DE
• Center for Arrhythmia Research,
University of Michigan, Ann Arbor
MI, US
• Centre of interdisciplinary EM,
EPF Lausanne, Lausanne, CH
• Département de Pathologie,
EPF Lausanne, CH
• Department of Biochemistry,
University of Cambridge, GB
• Department of Nephrology and
Hypertension, University Hospital,
Bern, CH
• Department of Pharmacology,
University of Calabria, Arcavacata
di Rende, IT
• Department of Structural Biology,
Free University of Brussels,
Brussels, BE
• Department of Surgery & Cancer,
Imperial College, London, GB
• Equipe Biologie des Métaux,
Institut de Recherches en
Technologies et Sciences pour le
Vivant, Grenoble, FR
• Faculté de Médecine, Centre de
Recherche en Neurobiologie et
Neurophysiologie, UMR6231-
CNRS-Universite Aix-Marseille II
et III, Marseille, FR
• Hematology, St. Jude Children’s
Hospital, Memphis, US
• Immunology, Alexander Fleming
Biomedical Sciences Research
Center, Vari, GR
• Institut du Thorax, Université de
Nantes, FR
• Institute for Neurodegenerative
Diseases, University of California,
San Francisco, US
• Institute for Research in
Biomedicine, University of
Barcelona, Barcelona, ES
• Institute of Clinical Chemistry,
University of Zurich, Zurich, CH
Heads and Co-Leaders of Individual Research Projects and Facilities
Abriel Hugues, Prof.
Albrecht Christiane, Prof.
Altmann Karl-Heinz, Prof
Anderle Pascale, Dr.
Baumann Marc, Dr.
Bezzi Paola, Dr.
Dutzler Raimund, Prof.
Fotiadis Dimitrios J., Prof.
Fuster Daniel G., Dr.
Gertsch Jürg, Prof.
Hediger Matthias, Prof.
Hofstetter Wilhelm, Prof.
Locher Kaspar, Prof.
Lochner Martin, Prof.
Niggli Ernst, Prof.
Reymond Jean-Louis, Prof.
Stahlberg Henning, Prof.
Stieger Bruno, Prof.
Surbek Daniel, Prof.
Thorens Bernard, Prof.
Volterra Andrea, Prof.
Topics
The National Centre of
Competence in Research
(NCCR) “TransCure” is a
joint effort of a multidisciplinary
team of Swiss academic
experts who are focused on
cellular membrane transporter
research and its application
to the treatment of
human diseases. Using the
approach “from transport
physiology to the identification
of therapeutic targets”
researchers are working collaboratively,
sharing ideas,
and focusing on common
proteins and cellular pathways
related to membrane
transport. Transport proteins
and ion channels play
key roles in most physiological
processes in the human
body. They are gatekeepers
in the membranes of cells
and organelles and their
dysfunction contributes to
the pathogenesis of major
human diseases such as diabetes,
hypertension, cardiovascular
diseases, cancer,
preeclampsia, osteoporosis
and neurodegenerative diseases.
Thus, these proteins
have a great, unexplored
potential for the development
of novel therapeutic
strategies. The collaborative
efforts of TransCure combine
a unique interdisciplinary
skill set to be applied to
the developing therapeutic
strategies by controlling the
function of strategically important
transporters in the
diseased states. The skillset
encompasses three major
disciplines, referred to as
“TransCure Trias”: Physiology/Medicine,
Structural Biology
and Medicinal Chemistry.
TransCure members
and programs are localized
in many institutions
across Switzerland and the
TransCure approach is designed
to facilitate collaboration
and coordination of
activities with an entrepreneurial
spirit. The outcome
of the NCCR TransCure project
is expected to help develop
strategies to improve
human health.
Departement Klinische Forschung, Universität Bern
Institut für Biochemie und Molekulare Medizin, Universität Bern
Institut für Pharmazeutische Wissenschaften, ETH Zürich
Institut für Biochemie und Molekulare Medizin, Universität Bern
Abteilung für Frauenheilkunde, Universitätsspital Bern
Département de biologie cellulaire et de morphologie,
Université de Lausanne
Biochemisches Institut, Universität Zürich
Institut für Biochemie und Molekulare Medizin, Universität Bern
Institut für Biochemie und Molekulare Medizin, Universität Bern
Institut für Biochemie und Molekulare Medizin, Universität Bern
Institut für Biochemie und Molekulare Medizin, Universität Bern
Departement Klinische Forschung, Universität Bern
Institut für Molekulare Biologie und Biophysik, ETH Zürich
Institut für Chemie und Biochemie, Universität Bern
Institut für Physiologie, Universität Bern
Institut für Chemie und Biochemie, Universität Bern
Biozentrum, Universität Basel
Abteilung für Klinische Pharmakologie und Toxikologie,
Universitätsspital Zürich
Abteilung für Frauenheilkunde, Universitätsspital Bern
Center for Integrative Genomics, Université de Lausanne
Département de biologie cellulaire et de morphologie,
Université de Lausanne
Members of the International Advisory Board
Aguet Michel, Prof.
Swiss Institute for Experimental Cancer Research (ISREC), EPFL
Burrier Robert, Dr.
Stemina Biomarker Discovery, Madison, US
Grütter Markus, Prof.
Biochemisches Institut, Universität Zürich
32 | Guide 2013