Simulation of Clinical Trials with Mathematical Models ... - CBI

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Goals • Describe role of simulating clinical trials in comparative effectiveness research (CER) – Use Archimedes Model as example • Show examples – Case studies of diabetes treatments – Describe a tool for comparing >20 interventions for cardiometabolic risk 2
Topics • Rationale, mechanisms, and challenges of simulating clinical trials • Archimedes Model – Overview – Validation – Capabilities and applications • Case Studies – DPP expansion and extension – A-L-L – Results of 20 simulated trials of interventions for cardiometabolic risk 3
Page 1: Simulation of Clinical Trials with
Page 5 and 6: There are several ways to try to pr
Page 7 and 8: Topics • Rationale, mechanisms, a
Page 9 and 10: 9 Physiological Pathways are Repres
Page 11 and 12: 11 The Model is clinically and admi
Page 13 and 14: Over 50 trials have been used to va
Page 15 and 16: The Model can enhance trial design,
Page 17 and 18: Only simulation modeling could have
Page 19 and 20: 19 This enabled generation of longi
Page 21 and 22: In simulation, the DPP trial was si
Page 23 and 24: Estimating longitudinal cost outcom
Page 25 and 26: Simulation enabled trial expansion
Page 27 and 28: A-L-L: Clinical trial simulation en
Page 29 and 30: 29 A-L-L has a bigger effect than 1
Page 31 and 32: 31 CMI Independent Evaluation (2007
Page 33 and 34: A population dataset with pre-run i
Page 35 and 36: Health and cost outcomes can be cap
Page 37 and 38: Appendix www.archimedesmodel.com ..
Page 39 and 40: Publications • Age at initiation
Page 41 and 42: 41 The validation approach is rigor
Page 43 and 44: Fraction of patients 43 The Model y
Page 45 and 46: In the DPP simulation, populations
Page 47 and 48: Cost/ QALY DPP simulation also enab
Page 49 and 50: A-L-L: The savings begin immediatel

Simulation of Clinical Trials with Mathematical Models ... - CBI

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