Simulation of Clinical Trials with Mathematical Models ... - CBI
Simulation of Clinical Trials with Mathematical Models ... - CBI
Simulation of Clinical Trials with Mathematical Models ... - CBI
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A population dataset <strong>with</strong> pre-run interventions serves as a reference tool<br />
for development and implementation <strong>of</strong> novel approaches/medications<br />
Alternate <strong>Simulation</strong> Tool for CE: Cardio-Metabolic Risk Dataset<br />
Population<br />
Cardiometabolic<br />
interventions<br />
Treatment<br />
scenarios<br />
Settings<br />
• 100,000 individuals<br />
• Drawn from NHANES data 1999-2006<br />
• Subpopulations by age, gender, risk factors (e.g., CAD, DM)<br />
• Weight management<br />
• BP management<br />
• Cholesterol management<br />
• Medications (e.g., aspirin)<br />
• Glycemia management<br />
• Smoking cessation<br />
• Guidelines followed perfectly<br />
• Medications initiated at study start <strong>with</strong> no future adjustments<br />
• “Magic pills” - Medications that maintain outcome goal (e.g., LDL
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