Simulation of Clinical Trials with Mathematical Models ... - CBI
Simulation of Clinical Trials with Mathematical Models ... - CBI
Simulation of Clinical Trials with Mathematical Models ... - CBI
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<strong>Simulation</strong> enabled trial expansion and<br />
extension at a fraction <strong>of</strong> the cost <strong>of</strong> a real trial<br />
25<br />
Results<br />
Actual Trial<br />
Simulated Trial<br />
Size N=3,234 N=10,000<br />
Trial arms 3 3 + 1<br />
Mean trial duration 3.2 years 30 years<br />
Rates <strong>of</strong> diabetes • Current care: 28.9%<br />
• Metformin: 21.7%<br />
• Lifestyle: 14.4%<br />
27.4%<br />
21.9%<br />
13.2%<br />
Trial cost >$300M
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