Simulation of Clinical Trials with Mathematical Models ... - CBI
Simulation of Clinical Trials with Mathematical Models ... - CBI
Simulation of Clinical Trials with Mathematical Models ... - CBI
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The approach involved matching populations, care<br />
protocols, and costs<br />
Approach<br />
• Created a simulated population representing all<br />
diabetics over 55 years in Kaiser Permanente (CA)<br />
• Constructed trial <strong>with</strong> three groups:<br />
– Current care (based on national guidelines and realistic<br />
performance and compliance)<br />
– A-L-L regimen on top <strong>of</strong> Current Care<br />
– Reference group: 1% HbA1c reduction<br />
• Used KP’s costs for drugs, lab tests, <strong>of</strong>fice visits, and<br />
admissions for MIs and strokes<br />
• Set duration <strong>of</strong> simulated trial at 30 years<br />
********<br />
• KP’s Care Management Institute conducted an<br />
independent real trial (2 years) to evaluate A-L-L<br />
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