Simulation of Clinical Trials with Mathematical Models ... - CBI

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The Model is clinically and administratively detailed in following care processes 40 Modeling health care processes and clinical practice guidelines (e.g. ATP III)
41 The validation approach is rigorous People Treatments Randomized Controlled <strong>Trials</strong> Real Outcomes Same (Virtual) People Same (Virtual) Treatments Same? Virtual Outcomes
Page 1 and 2: Simulation of Clinical Trials with
Page 3 and 4: Topics • Rationale, mechanisms, a
Page 5 and 6: There are several ways to try to pr
Page 7 and 8: Topics • Rationale, mechanisms, a
Page 9 and 10: 9 Physiological Pathways are Repres
Page 11 and 12: 11 The Model is clinically and admi
Page 13 and 14: Over 50 trials have been used to va
Page 15 and 16: The Model can enhance trial design,
Page 17 and 18: Only simulation modeling could have
Page 19 and 20: 19 This enabled generation of longi
Page 21 and 22: In simulation, the DPP trial was si
Page 23 and 24: Estimating longitudinal cost outcom
Page 25 and 26: Simulation enabled trial expansion
Page 27 and 28: A-L-L: Clinical trial simulation en
Page 29 and 30: 29 A-L-L has a bigger effect than 1
Page 31 and 32: 31 CMI Independent Evaluation (2007
Page 33 and 34: A population dataset with pre-run i
Page 35 and 36: Health and cost outcomes can be cap
Page 37 and 38: Appendix www.archimedesmodel.com ..
Page 39: Publications • Age at initiation
Page 43 and 44: Fraction of patients 43 The Model y
Page 45 and 46: In the DPP simulation, populations
Page 47 and 48: Cost/ QALY DPP simulation also enab
Page 49 and 50: A-L-L: The savings begin immediatel

Simulation of Clinical Trials with Mathematical Models ... - CBI

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