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Simulation of Clinical Trials with Mathematical Models ... - CBI

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Topics<br />

• Rationale, mechanisms, and challenges <strong>of</strong> simulating<br />

clinical trials<br />

• Archimedes Model<br />

– Overview<br />

– Validation<br />

– Capabilities and applications<br />

• Case Studies<br />

– DPP expansion and extension<br />

– A-L-L<br />

– Results <strong>of</strong> 20 simulated trials <strong>of</strong> interventions for<br />

cardiometabolic risk<br />

32

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