Simulation of Clinical Trials with Mathematical Models ... - CBI
Simulation of Clinical Trials with Mathematical Models ... - CBI
Simulation of Clinical Trials with Mathematical Models ... - CBI
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Estimating longitudinal health outcomes<br />
generated CE insight (Baseline vs. Lifestyle)<br />
Without Lifestyle (baseline)<br />
Difference <strong>with</strong> Lifestyle<br />
Years <strong>of</strong> follow-up 10 20 30 10 20 30<br />
Diabetes 56.9% 68.6% 72.2% -14.3% -11.6% -10.8%<br />
CAD//CHF<br />
Have an MI 4.0% 8.5% 12.0% -0.4% -1.1% -1.7%<br />
Develop CHF (systolic or diastolic) 0.2% 0.7% 1.2% -0.1% -0.1% -0.1%<br />
Stroke (ischemic or hemorrhagic) 2.9% 7.0% 11.6% -0.5% -1.0% -1.4%<br />
Some serious complication 11.2% 26.1% 38.2% -3% -6.6% -8.4%<br />
Deaths<br />
22% 17% decrease<br />
CHD 2.2% 6.6% 11.9% -0.6% -1.1% -2.0%<br />
Stroke 0.4% 0.9% 1.5% -0.1% -0.3% -0.3%<br />
Renal disease 0.00% 0.02% 0.1% 0.00% -0.01% -0.04%<br />
Death from any complication 2.6% 7.6% 13.5% -0.7% -1.3% -2.3%<br />
Life Years 24.032 0.288<br />
22<br />
22
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