Simulation of Clinical Trials with Mathematical Models ... - CBI
Simulation of Clinical Trials with Mathematical Models ... - CBI
Simulation of Clinical Trials with Mathematical Models ... - CBI
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A-L-L: <strong>Clinical</strong> trial simulation enabled testing<br />
<strong>of</strong> a novel hypothesis<br />
Situation<br />
• A group <strong>of</strong> physicians at Kaiser Permanente<br />
suggested that a combination <strong>of</strong> aspirin, lovastatin,<br />
and lisinopril would reduce complications <strong>of</strong><br />
diabetes<br />
• However, there was no direct evidence and no way<br />
to determine effects on health outcomes and costs<br />
• Yet, data would be needed to support adoption<br />
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