Simulation of Clinical Trials with Mathematical Models ... - CBI
Simulation of Clinical Trials with Mathematical Models ... - CBI
Simulation of Clinical Trials with Mathematical Models ... - CBI
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Cumulative Incidence <strong>of</strong> Diabetes<br />
20<br />
The simulation was prospectively validated<br />
against the original trial<br />
0.5<br />
DPP: Diabetes Progression<br />
0.45<br />
0.4<br />
0.35<br />
0.3<br />
0.25<br />
0.2<br />
0.15<br />
0.1<br />
0.05<br />
0<br />
Current<br />
28.9% 27.4%<br />
0 0.5 1 1.5 2 2.5 3 care 3.5 4<br />
Time (years)<br />
3-Yr<br />
Timepoint<br />
Actual<br />
control<br />
metformin<br />
lifestyle<br />
Simulated<br />
Metformin 21.7% 21.9%<br />
Lifestyle 14.4% 13.2%
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