What Is A Free Radical - Ãstav lÃ©kaÅskÃ© chemie a biochemie

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NO causes relaxation of smooth muscles in blood vessel wall: Reactive Nitrogen Species (RNS) • <strong>Radical</strong>s: – Nitric oxide, NO· – Nitric dioxide, NO 2 · • Non-radicals: – Nitrosonium, NO + – Nitroxyl, NO – – Nitrous acid, HNO 2 – Dinitrogen trioxide, N 2 O 3 – Dinitrogen tetraoxide, N 2 O 4 – Nitronium, NO 2 + – Peroxynitrite, ONOO – – Alkylperoxynitrite, ROONO 12
Oxidative damage to biomolecules • Lipids: peroxidation of polyunsaturated fatty acids in membranes • Proteins: oxidation of -SH, carbonylation - NH 2 , hydroxylation/nitrosylation of aromatic AA, cross-linking, degradation • Nucleic acids: strand breaks, hydroxylation of bases ... mutation, cancerogenesis Lipid peroxidation (rancidity) 13
Page 1 and 2: Reactive Oxygen Species in the Body
Page 4 and 5: Spin restriction of dioxygen • No
Page 6 and 7: Reactive oxygen species (ROS, ‘ox
Page 8 and 9: Origin of superoxide from oxyhemogl
Page 10 and 11: Hydroxyl radical • Formation in t
Page 14 and 15: Further fate of lipid peroxides Ion
Page 16 and 17: Beneficial ROS: Respiratory burst o
Page 18 and 19: …and very complex Oxidative stres
Page 20 and 21: Antioxidant defence of human body
Page 22 and 23: Mitochondria originated from phagoc
Page 24 and 25: Glutathione (GSH/GSSG) • tripepti
Page 26 and 27: Peroxiredoxin/Thioredoxin • Recen
Page 28 and 29: ICT ECT Superoxide Peroxide Fe/Cu S
Page 30 and 31: Ascorbate in the body: • Main fun
Page 32 and 33: Antioxidant defence V Stress respon
Page 34: Free radicals in pathogenesis of hu

What Is A Free Radical - Ãstav lÃ©kaÅskÃ© chemie a biochemie

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What Is A Free Radical - Ãstav lÃ©kaÅskÃ© chemie a biochemie