What Is A Free Radical - Ãstav lékaÅské chemie a biochemie
What Is A Free Radical - Ãstav lékaÅské chemie a biochemie
What Is A Free Radical - Ãstav lékaÅské chemie a biochemie
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ICT<br />
ECT<br />
Superoxide<br />
Peroxide<br />
Fe/Cu<br />
Superoxide<br />
Peroxide<br />
Fe/Cu<br />
Superoxide dismutase<br />
Glutathione peroxidase<br />
Catalase<br />
Glutathione<br />
Tocopherol<br />
Ascorbate<br />
Labile iron pool (LIP) present<br />
Antioxidant enzymes &<br />
glutathione levels very low<br />
Tocopherol<br />
Ascorbate<br />
Carotenoids, uric acid, albumin,<br />
glucose, bilirubin...<br />
Sequestration of iron and copper:<br />
- transferrin, lactoferrin<br />
- hemopexin<br />
- haptoglobin<br />
- ceruloplasmin (ferroxidase)<br />
- Cu bound to albumin<br />
Antioxidant defence IV<br />
Low-molecular-weight antioxidant substrates<br />
• THIOLS:<br />
– Glutathione<br />
– Thioredoxin<br />
• OTHER ENDOGENOUS METABOLITES:<br />
– Bilirubin<br />
– Uric acid<br />
– Lipoic acid<br />
• DIETARY:<br />
– Ascorbate (Vitamin C)<br />
– α-Tocopherol (Vitamin E)<br />
– Carotenoids<br />
– Plant phenols<br />
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