What Is A Free Radical - Ãstav lÃ©kaÅskÃ© chemie a biochemie

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Peroxiredoxin/Thioredoxin • Recently discovered antioxidant system, more important for removal of hydrogen peroxide than GPX O 2·– Superoxide dismutase NADPH+H + H 2 O 2 Peroxiredoxin RED Thioredoxin RED Thioredoxin reductase RED SH HS SH HS FADH 2 (Se) GSH Peroxiredoxin OX Thioredoxin OX Thioredoxin reductase OX H 2 O S S S S FAD (Se) NADP + 26
Antioxidant defence III Sequestration of metals • Redox-active transition metals (Fe, Cu) accept/donate one electron easily – ... alleviation of spin restriction of dioxygen – ... metals are in active centers of all oxygen handlingenzymes • But, the same properties of Fe, Cu are deleterious if uncontrolled – the Fenton oxidant: H 2 O 2 + Fe 2+ → OH – + OH· + Fe 3+ oxidative damage to biomolecules Antioxidant defence III Sequestration of metals • Iron/copper handling proteins: – transferrin: binds 2 atoms Fe 3+ (transport) – lactoferrin: analogous to transferrin, but no Fe release (... only sequestration), leucocytes – ferritin: H and L subunits, H is ferroxidase, Fe storage (up to 4500 atoms Fe 3+ ) – haptoglobin: binds hemoglobin in circulation – hemopexin: binds heme in circulation – ceruloplasmin: contains Cu, function: ferroxidase (export Fe from the cells) – albumin: transport of Cu 27
Page 1 and 2: Reactive Oxygen Species in the Body
Page 4 and 5: Spin restriction of dioxygen • No
Page 6 and 7: Reactive oxygen species (ROS, ‘ox
Page 8 and 9: Origin of superoxide from oxyhemogl
Page 10 and 11: Hydroxyl radical • Formation in t
Page 12 and 13: NO causes relaxation of smooth musc
Page 14 and 15: Further fate of lipid peroxides Ion
Page 16 and 17: Beneficial ROS: Respiratory burst o
Page 18 and 19: …and very complex Oxidative stres
Page 20 and 21: Antioxidant defence of human body
Page 22 and 23: Mitochondria originated from phagoc
Page 24 and 25: Glutathione (GSH/GSSG) • tripepti
Page 28 and 29: ICT ECT Superoxide Peroxide Fe/Cu S
Page 30 and 31: Ascorbate in the body: • Main fun
Page 32 and 33: Antioxidant defence V Stress respon
Page 34: Free radicals in pathogenesis of hu

What Is A Free Radical - Ãstav lÃ©kaÅskÃ© chemie a biochemie

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What Is A Free Radical - Ãstav lÃ©kaÅskÃ© chemie a biochemie