What Is A Free Radical - Ústav lékařské chemie a biochemie

Beneficial ROS:
Respiratory
burst of
neutrophilic granulocyte
© 1998 Garland Publishing
Where RONS are beneficial:
• Monooxygenases: hydroxylation of steroids,
xenobiotics etc.
• Phagocyte weapons: killing microbes or cancer cells
• Mediators of inflammatory reaction
• Local hormones/mediators:
- NO:
- smooth muscle relaxation in blood vessels, gastrointestinal tract,
corpus cavernosum penis
- neurotransmitter/ neuromodulator in the CNS, function in
synaptic plasticity, learning & memory
- inhibition of thrombocyte adhesion & aggregation, leucocyte
adhesion
Superoxide as well with effects opposing NO ?
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