What Is A Free Radical - Ãstav lÃ©kaÅskÃ© chemie a biochemie

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Mitochondria originated from phagocyted/parasitic bacteria ... Antioxidant defence II Antioxidant enzymes • Superoxide dismutase: O 2·– + O 2·– + 2 H + → O 2 + H 2 O 2 • Catalase: 2 H 2 O 2 → 2 H 2 O + O 2 • Glutathione peroxidase, peroxiredoxin: H 2 O 2 + 2 R-SH → 2 H 2 O + RS-SR 22
Superoxide dismutase (SOD) • Catalyses dismutation of superoxide: O 2·– + O 2·– + 2 H + → O 2 + H 2 O 2 • Absolutely required for life in oxygen • SOD1: Cu+Zn (cytosol of eukaryotic cells) • SOD2: – Mn (mitochondrial matrix) – Fe (bacteria) • EC-SOD (SOD3): extracelullar, Cu+Zn, – MW 135,000; binds to heparane sulfate on the inner surface of blood vessels Glutathione peroxidases (GPX) • Reduction of peroxides coupled to oxidation of glutathione: 2 GSH + H 2 O 2 → GS-SG + 2 H 2 O (glutathione is subsequently regenerated by glutathione reductases) • Active site contains selenocysteine • Cytosolic glutathione peroxidase: – reduces H 2 O 2 and LOOH after release from phospholipids • Phospholipide hydroperoxide-GSH-peroxidase: – reduces LOOH even in membranes 23
Page 1 and 2: Reactive Oxygen Species in the Body
Page 4 and 5: Spin restriction of dioxygen • No
Page 6 and 7: Reactive oxygen species (ROS, ‘ox
Page 8 and 9: Origin of superoxide from oxyhemogl
Page 10 and 11: Hydroxyl radical • Formation in t
Page 12 and 13: NO causes relaxation of smooth musc
Page 14 and 15: Further fate of lipid peroxides Ion
Page 16 and 17: Beneficial ROS: Respiratory burst o
Page 18 and 19: …and very complex Oxidative stres
Page 20 and 21: Antioxidant defence of human body
Page 24 and 25: Glutathione (GSH/GSSG) • tripepti
Page 26 and 27: Peroxiredoxin/Thioredoxin • Recen
Page 28 and 29: ICT ECT Superoxide Peroxide Fe/Cu S
Page 30 and 31: Ascorbate in the body: • Main fun
Page 32 and 33: Antioxidant defence V Stress respon
Page 34: Free radicals in pathogenesis of hu

What Is A Free Radical - Ãstav lÃ©kaÅskÃ© chemie a biochemie

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What Is A Free Radical - Ãstav lÃ©kaÅskÃ© chemie a biochemie