What Is A Free Radical - Ãstav lÃ©kaÅskÃ© chemie a biochemie

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Antioxidant defence V Stress response Oxidation or nitrosylation of sensor -SH Transcription factors (NFκB, Nrf-2…): activation, nuclear translocation Induction of gene expression: • chaperones (heat shock proteins) • antioxidant enzymes • metallothionein • hemoxygenase 1 …→ more resistant to further oxidative stress Apoptosis as the ultimate antioxidant defence ? 32
Why red blood cells need pentose phosphate cycle? 2 O 2·– +2H + H 2 O 2 + O 2 Superoxide dismutase NADP + H 2 O Glutathione peroxidase Glutathione reductase Methemoglobin reductase Hb-FeII NADPH+H + Hb-FeIII Pentose phosphate pathway 33
Page 1 and 2: Reactive Oxygen Species in the Body
Page 4 and 5: Spin restriction of dioxygen • No
Page 6 and 7: Reactive oxygen species (ROS, ‘ox
Page 8 and 9: Origin of superoxide from oxyhemogl
Page 10 and 11: Hydroxyl radical • Formation in t
Page 12 and 13: NO causes relaxation of smooth musc
Page 14 and 15: Further fate of lipid peroxides Ion
Page 16 and 17: Beneficial ROS: Respiratory burst o
Page 18 and 19: …and very complex Oxidative stres
Page 20 and 21: Antioxidant defence of human body
Page 22 and 23: Mitochondria originated from phagoc
Page 24 and 25: Glutathione (GSH/GSSG) • tripepti
Page 26 and 27: Peroxiredoxin/Thioredoxin • Recen
Page 28 and 29: ICT ECT Superoxide Peroxide Fe/Cu S
Page 30 and 31: Ascorbate in the body: • Main fun
Page 34: Free radicals in pathogenesis of hu

What Is A Free Radical - Ãstav lÃ©kaÅskÃ© chemie a biochemie

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What Is A Free Radical - Ãstav lÃ©kaÅskÃ© chemie a biochemie