What Is A Free Radical - Ãstav lÃ©kaÅskÃ© chemie a biochemie

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Antioxidant defence of human body • Anatomy of the body limiting tissue oxygen • Antioxidant enzymes • Sequestration of redox active metals • Antioxidant substrates (scavengers) • Stress response • (Repair systems) O 2 First organism (anaerobic) ? Develop antioxidant defence ? Die out ? Resort to anaerobic condition ? 20
Clump together ! O 2 O 2 Antioxidant defence I Regulation of tissue O 2 Inhaled air: 160 mmHg O 2 Lung capillaries: 100 mmHg O 2 Arterial blood: 85 mmHg O 2 Arterioles: 70 mmHg O 2 Capillaries: 50 mmHg O 2 Cells: 1-10 mmHg O 2 Mitochondria: < 0,5 mmHg O 2 Fig: Wikipedia 21
Page 1 and 2: Reactive Oxygen Species in the Body
Page 4 and 5: Spin restriction of dioxygen • No
Page 6 and 7: Reactive oxygen species (ROS, ‘ox
Page 8 and 9: Origin of superoxide from oxyhemogl
Page 10 and 11: Hydroxyl radical • Formation in t
Page 12 and 13: NO causes relaxation of smooth musc
Page 14 and 15: Further fate of lipid peroxides Ion
Page 16 and 17: Beneficial ROS: Respiratory burst o
Page 18 and 19: …and very complex Oxidative stres
Page 22 and 23: Mitochondria originated from phagoc
Page 24 and 25: Glutathione (GSH/GSSG) • tripepti
Page 26 and 27: Peroxiredoxin/Thioredoxin • Recen
Page 28 and 29: ICT ECT Superoxide Peroxide Fe/Cu S
Page 30 and 31: Ascorbate in the body: • Main fun
Page 32 and 33: Antioxidant defence V Stress respon
Page 34: Free radicals in pathogenesis of hu

What Is A Free Radical - Ãstav lÃ©kaÅskÃ© chemie a biochemie

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What Is A Free Radical - Ãstav lÃ©kaÅskÃ© chemie a biochemie