What Is A Free Radical - Ãstav lÃ©kaÅskÃ© chemie a biochemie

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$(Microsoft PowerPoint - ATP angl.ppt [Re\236im kompatibility])$

Spin restriction of dioxygen • Normal (triplet) O 2 is a biradical, with high affinity to electrons • But gain of an electron requires one of the unpaired electrons changes its spin, which is a slow process. • That’s why we do not burn in the air • Singlet O 2 is an excited, highly reactive species Respiratory chain in the mitochondrial inner membrane 4
The respiratory chain: ..ele electrons flow ‘downhill’ and terminate at oxygen Overall reaction: NADH + H + + 1/2 O 2 → NAD + + H 2 O ∆G o ’ = –219.25 kJ mol -1 ..and resulting proton gradient powersp ATP synthesis 5
Page 1 and 2: Reactive Oxygen Species in the Body
Page 6 and 7: Reactive oxygen species (ROS, ‘ox
Page 8 and 9: Origin of superoxide from oxyhemogl
Page 10 and 11: Hydroxyl radical • Formation in t
Page 12 and 13: NO causes relaxation of smooth musc
Page 14 and 15: Further fate of lipid peroxides Ion
Page 16 and 17: Beneficial ROS: Respiratory burst o
Page 18 and 19: …and very complex Oxidative stres
Page 20 and 21: Antioxidant defence of human body
Page 22 and 23: Mitochondria originated from phagoc
Page 24 and 25: Glutathione (GSH/GSSG) • tripepti
Page 26 and 27: Peroxiredoxin/Thioredoxin • Recen
Page 28 and 29: ICT ECT Superoxide Peroxide Fe/Cu S
Page 30 and 31: Ascorbate in the body: • Main fun
Page 32 and 33: Antioxidant defence V Stress respon
Page 34: Free radicals in pathogenesis of hu

What Is A Free Radical - Ãstav lÃ©kaÅskÃ© chemie a biochemie

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What Is A Free Radical - Ãstav lÃ©kaÅskÃ© chemie a biochemie