TUMOR IMMUNOLOGY.pdf

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Army of the host to fight cancers Antibody Macrophage Cancer cell Helper T cell cytokine NK cell chemokine Dendritic cell Cytotoxic T cell
Page 1 and 2: Cancer Immunology and Immunotherapy
Page 3 and 4: Definitions of Cancer • Cancer co
Page 5 and 6: Neoplastic Transformation -- Carcin
Page 7 and 8: Current strategies to combat cancer
Page 9 and 10: Cancer Immunology and Immunotherapy
Page 11: Cancer Immunosurveilance • The hy
Page 16 and 17: Cytotoxic T cells (CTLs) CD8+ T cel
Page 18 and 19: Dendritic Cells The professional an
Page 20 and 21: Cytokines • Regulating the innate
Page 22 and 23: Tumor elimination
Page 24 and 25: Cancer Immunology/Immunotherapy •
Page 26 and 27: How cancer cells avoid immunosurvei
Page 28 and 29: (2) Down-regulation, mutation or lo
Page 30 and 31: (3) Loss of costimulation Costimula
Page 32 and 33: The initiation of T cell responses
Page 34: (5) Immunosuppressive cytokines •
Page 37 and 38: Regulatory T Cells T cells compete
Page 39 and 40: Possible suppressive mechanisms reg
Page 41 and 42: Summary: Main defences of the tumor
Page 43 and 44: • Immune defects in T cells • M
Page 45 and 46: Tumor mass Vessel Lymphocyte FasL+
Page 47 and 48: Tumor-derived factors with DC inhib
Page 50 and 51: Activation versus suppression of im
Page 52 and 53: The defense of tumor overweighs the
Page 54 and 55: Tumor Immunotherapy Strategies to i
Page 56 and 57: Strategies to supplement the missin
Page 58 and 59: Main Mechanisms of Immunotherapy
Page 60 and 61: Current Immunotherapeutic strategie
Page 62 and 63: Antibody Therapy Rituximab: The fir
Page 64 and 65:
Local and regional IL-2 administrat
Page 66 and 67:
Tumor escape mechanism and T-cell a
Page 68 and 69:
Antitumor Vaccines Administration o
Page 70 and 71:
Antitumor Vaccines
Page 72 and 73:
Dendritic Cells That Attack Cancer
Page 74:
Examples from my research work
Page 77 and 78:
Gene transfer of antisense hypoxia
Page 79 and 80:
B7H3-meidated Cancer Immunotherapy
Page 81 and 82:
Gene transfer results in expression
Page 83 and 84:
Production of anti-tumor cytokine a
Page 85 and 86:
Conclusion • Immunotherapy may be
Page 87:
DR Kevin Sun Department of Molecula
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