TUMOR IMMUNOLOGY.pdf
TUMOR IMMUNOLOGY.pdf
TUMOR IMMUNOLOGY.pdf
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Mechanisms of cancer escape from<br />
the Immunosurveilance<br />
1. Altering Their Characteristics ti :<br />
Loss/downregulation of MHC class I<br />
Down-regulation regulation, mutation, or loss of tumor antigens<br />
Loss of costimulation<br />
2. Suppressing the Immune Response :<br />
ineffective signals to CTL<br />
Alteration in cell death receptor signaling<br />
Immunosuppressive cytokine<br />
3. Outpacing the Immune Response: Tumour cells<br />
can simply pyproliferate so quickly that the immune<br />
response is not fast enough to keep their growth<br />
in check
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