TUMOR IMMUNOLOGY.pdf

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Novel co-stimulatory molecule- B7H3 Molecular Structure SS IgV-like IgC-like Cytoplasmic Transmembrance Signal peptide MLRGWGGPSVGVCVRTALGVLCLCLTGAVEVQVSEDPVVALVDTDATLRC IgV-like domain SFSPEPGFSLAQLNLIWQLTDTKQLVHSFTEGRDQGSAYSNRTALFPDLLVQ GNASLRLQRVRVTDEGSYTCFVSIQDFDSAAVSLQVAAPYSKPSMTLEPNK IgC-like domain DLRPGNMVTITCSSYQGYPEAEVFWKDGQGVPLTGNVTTSQMANERGLFD VHSVLRVVLGANGTYSCLVRNPVLQQDAHGSVTITGQPLTFPPEALWVTVG Transmembrane Cytoplasmic LSVCLVVLLVALAFVCWRKIKQSCEDENAGAEDQDGDGEGSKTALRPLKPS ENKEDDGQEIA Sun X, et al. Gene Therapy 2003; 10:1728-1734.
Gene transfer results in expression of B7H3 on the surface of tumor cells pcDNA3.1 Flag-B7H3 Flag-B7H3 Tubulin
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Cancer Immunology and Immunotherapy
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Definitions of Cancer • Cancer co
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Neoplastic Transformation -- Carcin
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Current strategies to combat cancer
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Cancer Immunology and Immunotherapy
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Cancer Immunosurveilance • The hy
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Army of the host to fight cancers A
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Helper T cells CD4+ T cells: reacti
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Other cells NK cells: after activat
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Antibody - produced by B cells •
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How does cancer Single cancer cell
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Mechanisms of cancer escape from th
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(1) Loss/down-regulation of HLA cla
Page 29 and 30: Tumor Antigens • Altered self: K-
Page 31 and 32: T cell Activation T cell No Activat
Page 33 and 34: (4) Alterations in cell death recep
Page 36 and 37: (6) Induction of Immunosuppressive
Page 38 and 39: Potential sources for regulatory T
Page 40 and 41: (7) Production of other suppressive
Page 42 and 43: 1. Weapons from the tumors 2. Defec
Page 44 and 45: Immune defects in T cells in cancer
Page 46 and 47: Malfunction of dendritic cell syste
Page 48: Summary How do tumors progress
Page 51 and 52: The fortune of tumor cells depends
Page 53 and 54: Cancer Immunology/Immunotherapy •
Page 55 and 56: Immunotherapy --- Reverse the imbal
Page 57 and 58: Strategies to block the suppressive
Page 59 and 60: History: Non-specific approach •
Page 61 and 62: Examples
Page 63 and 64: Event Discovery of IL-2 Cytokine th
Page 65 and 66: Adoptive immunotherapy • Stimulat
Page 67 and 68: Adoptive immunotherapy The Journal
Page 69 and 70: Antitumor Vaccines
Page 71 and 72: Approaches to antitumor vaccination
Page 73 and 74: Combinational Therapy -- a three-st
Page 76 and 77: The immune system can be harnessed
Page 78 and 79: Potential mechanisms for synergy di
Page 82 and 83: Combinational therapy led to eradic
Page 84 and 85: Treatment of single tumor eradicate
Page 86 and 87: Background - mini review Introducti
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