TUMOR IMMUNOLOGY.pdf

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Potential mechanisms for synergy displayed by combined blocking hypoxia pathway and B7.1-mediated immunotherapy NK Apoptosis Tumor cell v v Tumor cell v Tumor cell B7.1 Necrosis B7.1+AS-HIF Activates NK cells AS-HIF Anti-angiogenesis + hsp70- tumor Antigen Glycolysis B7.1 APC MHCI CD28 T cell MHCII CD28 Tumor C cell B7.1 MHCI T cell Proliferation & CTLmediated killing MHCII Heat-shock di driven antitumor immunity Cell vitality Immune suppressive elements Tumor Cell Apoptosis
B7H3-meidated Cancer Immunotherapy Arsenic trioxide synergizes with B7H3-mediated immunotherapy to eradicate hepatocellular carcinomas International Journal of Cancer 2006; 118:1823-1830. Complete eradication of fhepatocellular l carcinomas by combined vasostatin gene therapy and B7H3-mediated immunotherapy. Journal of Hepatology 2007;46: 98-106
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Cancer Immunology and Immunotherapy
Page 3 and 4:
Definitions of Cancer • Cancer co
Page 5 and 6:
Neoplastic Transformation -- Carcin
Page 7 and 8:
Current strategies to combat cancer
Page 9 and 10:
Cancer Immunology and Immunotherapy
Page 11:
Cancer Immunosurveilance • The hy
Page 14:
Army of the host to fight cancers A
Page 17 and 18:
Helper T cells CD4+ T cells: reacti
Page 19 and 20:
Other cells NK cells: after activat
Page 21 and 22:
Antibody - produced by B cells •
Page 23 and 24:
How does cancer Single cancer cell
Page 25 and 26:
Mechanisms of cancer escape from th
Page 27 and 28: (1) Loss/down-regulation of HLA cla
Page 29 and 30: Tumor Antigens • Altered self: K-
Page 31 and 32: T cell Activation T cell No Activat
Page 33 and 34: (4) Alterations in cell death recep
Page 36 and 37: (6) Induction of Immunosuppressive
Page 38 and 39: Potential sources for regulatory T
Page 40 and 41: (7) Production of other suppressive
Page 42 and 43: 1. Weapons from the tumors 2. Defec
Page 44 and 45: Immune defects in T cells in cancer
Page 46 and 47: Malfunction of dendritic cell syste
Page 48: Summary How do tumors progress
Page 51 and 52: The fortune of tumor cells depends
Page 53 and 54: Cancer Immunology/Immunotherapy •
Page 55 and 56: Immunotherapy --- Reverse the imbal
Page 57 and 58: Strategies to block the suppressive
Page 59 and 60: History: Non-specific approach •
Page 61 and 62: Examples
Page 63 and 64: Event Discovery of IL-2 Cytokine th
Page 65 and 66: Adoptive immunotherapy • Stimulat
Page 67 and 68: Adoptive immunotherapy The Journal
Page 69 and 70: Antitumor Vaccines
Page 71 and 72: Approaches to antitumor vaccination
Page 73 and 74: Combinational Therapy -- a three-st
Page 76 and 77: The immune system can be harnessed
Page 80 and 81: Novel co-stimulatory molecule- B7H3
Page 82 and 83: Combinational therapy led to eradic
Page 84 and 85: Treatment of single tumor eradicate
Page 86 and 87: Background - mini review Introducti
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