TUMOR IMMUNOLOGY.pdf

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Cancer Immunology/Immunotherapy • How does the immune system eliminate cancer cells • How do cancer cells escape from Immunosurveilance • How can we help to win the battle between immune system and cancers – Cancer immunotherapy • Examples
Mechanisms of cancer escape from the Immunosurveilance 1. Altering Their Characteristics ti : Loss/downregulation of MHC class I Down-regulation regulation, mutation, or loss of tumor antigens Loss of costimulation 2. Suppressing the Immune Response : ineffective signals to CTL Alteration in cell death receptor signaling Immunosuppressive cytokine 3. Outpacing the Immune Response: Tumour cells can simply pyproliferate so quickly that the immune response is not fast enough to keep their growth in check
Page 1 and 2: Cancer Immunology and Immunotherapy
Page 3 and 4: Definitions of Cancer • Cancer co
Page 5 and 6: Neoplastic Transformation -- Carcin
Page 7 and 8: Current strategies to combat cancer
Page 9 and 10: Cancer Immunology and Immunotherapy
Page 11: Cancer Immunosurveilance • The hy
Page 14: Army of the host to fight cancers A
Page 17 and 18: Helper T cells CD4+ T cells: reacti
Page 19 and 20: Other cells NK cells: after activat
Page 21 and 22: Antibody - produced by B cells •
Page 23: How does cancer Single cancer cell
Page 27 and 28: (1) Loss/down-regulation of HLA cla
Page 29 and 30: Tumor Antigens • Altered self: K-
Page 31 and 32: T cell Activation T cell No Activat
Page 33 and 34: (4) Alterations in cell death recep
Page 36 and 37: (6) Induction of Immunosuppressive
Page 38 and 39: Potential sources for regulatory T
Page 40 and 41: (7) Production of other suppressive
Page 42 and 43: 1. Weapons from the tumors 2. Defec
Page 44 and 45: Immune defects in T cells in cancer
Page 46 and 47: Malfunction of dendritic cell syste
Page 48: Summary How do tumors progress
Page 51 and 52: The fortune of tumor cells depends
Page 53 and 54: Cancer Immunology/Immunotherapy •
Page 55 and 56: Immunotherapy --- Reverse the imbal
Page 57 and 58: Strategies to block the suppressive
Page 59 and 60: History: Non-specific approach •
Page 61 and 62: Examples
Page 63 and 64: Event Discovery of IL-2 Cytokine th
Page 65 and 66: Adoptive immunotherapy • Stimulat
Page 67 and 68: Adoptive immunotherapy The Journal
Page 69 and 70: Antitumor Vaccines
Page 71 and 72: Approaches to antitumor vaccination
Page 73 and 74: Combinational Therapy -- a three-st
Page 76 and 77:
The immune system can be harnessed
Page 78 and 79:
Potential mechanisms for synergy di
Page 80 and 81:
Novel co-stimulatory molecule- B7H3
Page 82 and 83:
Combinational therapy led to eradic
Page 84 and 85:
Treatment of single tumor eradicate
Page 86 and 87:
Background - mini review Introducti
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