TUMOR IMMUNOLOGY.pdf
TUMOR IMMUNOLOGY.pdf
TUMOR IMMUNOLOGY.pdf
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Summary: Main defences of the<br />
tumors against immunity<br />
1) Alteration of MHC class I and tumor antigen expression<br />
2) Dysregulated expression of adhesion / costimulatory<br />
molecules by tumor and/or antigen-presenting cells<br />
3) Changes in T-cell signal transduction molecules, i.e. cell death<br />
receptor signalling<br />
4) Induction of immune suppressive cytokines<br />
5) Induction of immunosuppressive cells<br />
6) Secretion of suppressive factors
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